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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1772928
Target Type SINGLE PROTEIN
Preferred Name ATP-binding cassette sub-family B member 5
Synonyms ABCB5 P-gp | ABCB5 | ATP-binding cassette sub-family B member 5 | P-glycoprotein ABCB5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcb subfamily

Target Components

Component Description Relationship Accession
ATP-binding cassette sub-family B member 5 SINGLE PROTEIN Q2M3G0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000004846
Ensembl ENSG00000004846
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0015562 (efflux transmembrane transporter activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO Biological Process GO:0002481 (antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)
GO:0002485 (antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)
GO:0002489 (antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)
GO:0002591 (positive regulation of antigen processing and presentation of peptide antigen via MHC class I)
GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0030154 (cell differentiation)
GO:0042391 (regulation of membrane potential)
GO:0042908 (xenobiotic transport)
GO:0048058 (compound eye corneal lens development)
GO:0055085 (transmembrane transport)
Wikipedia ABCB5

Target Cross References - Protein

Human Protein Atlas ENSG00000004846
IntAct Q2M3G0
Open Targets ENSG00000004846
PharmGKB PA24387
Reactome R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt A4D131 A7BKA4 B5MD19 B7WPL1 F8QQP8 F8QQP9 J3KQ04 Q2M3G0 Q2M3I5 Q5I5Q7 Q5I5Q8 Q6KG50 Q6XFQ5 Q8IXA1

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
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