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Target Report Card

Target Name and Classification

Target ID CHEMBL1764940
Preferred Name Replication protein A 70 kDa DNA-binding subunit
Synonyms REPA1 | RF-A protein 1 | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Replication protein A 70 kDa DNA-binding subunit | Replication protein A 70 kDa DNA-binding subunit, N-terminally processed | Single-stranded DNA-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Replication protein A 70 kDa DNA-binding subunit SINGLE PROTEIN P27694

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885545 Cellular tumor antigen p53/Replication protein A 70 kDa DNA-binding subunit PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132383
Ensembl ENSG00000132383
GO Cellular Component GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005662 (DNA replication factor A complex)
GO:0016605 (PML body)
GO Molecular Function GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0005515 (protein binding)
GO:0046872 (metal ion binding)
GO:0098505 (G-rich strand telomeric DNA binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000723 (telomere maintenance)
GO:0000724 (double-strand break repair via homologous recombination)
GO:0006260 (DNA replication)
GO:0006261 (DNA-dependent DNA replication)
GO:0006281 (DNA repair)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006284 (base-excision repair)
GO:0006289 (nucleotide-excision repair)
GO:0006293 (nucleotide-excision repair, preincision complex stabilization)
GO:0006294 (nucleotide-excision repair, preincision complex assembly)
GO:0006295 (nucleotide-excision repair, DNA incision, 3'-to lesion)
GO:0006296 (nucleotide-excision repair, DNA incision, 5'-to lesion)
GO:0006297 (nucleotide-excision repair, DNA gap filling)
GO:0006298 (mismatch repair)
GO:0006310 (DNA recombination)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0019985 (translesion synthesis)
GO:0032201 (telomere maintenance via semi-conservative replication)
GO:0033683 (nucleotide-excision repair, DNA incision)
GO:0034502 (protein localization to chromosome)
GO:0036297 (interstrand cross-link repair)
GO:0042276 (error-prone translesion synthesis)
GO:0042769 (DNA damage response, detection of DNA damage)
GO:0070987 (error-free translesion synthesis)
GO:1900034 (regulation of cellular response to heat)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia Replication_protein_A1

Target Cross References - Protein

Human Protein Atlas ENSG00000132383
IntAct P27694
Open Targets ENSG00000132383
PharmGKB PA34651
Reactome R-HSA-110312 (Translesion synthesis by REV1.)
R-HSA-110314 (Recognition of DNA damage by PCNA-containing replication complex.)
R-HSA-110320 (Translesion Synthesis by POLH.)
R-HSA-174437 (Removal of the Flap Intermediate from the C-strand.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-3108214 (SUMOylation of DNA damage response and repair proteins.)
R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-3371511 (HSF1 activation.)
R-HSA-5358565 (Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).)
R-HSA-5358606 (Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).)
R-HSA-5651801 (PCNA-Dependent Long Patch Base Excision Repair.)
R-HSA-5655862 (Translesion synthesis by POLK.)
R-HSA-5656121 (Translesion synthesis by POLI.)
R-HSA-5656169 (Termination of translesion DNA synthesis.)
R-HSA-5685938 (HDR through Single Strand Annealing (SSA).)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5693616 (Presynaptic phase of homologous DNA pairing and strand exchange.)
R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-5696397 (Gap-filling DNA repair synthesis and ligation in GG-NER.)
R-HSA-5696400 (Dual Incision in GG-NER.)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-6783310 (Fanconi Anemia Pathway.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-68962 (Activation of the pre-replicative complex.)
R-HSA-69166 (Removal of the Flap Intermediate.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
R-HSA-912446 (Meiotic recombination.)
UniProt A8K0Y9 P27694 Q59ES9

Target Cross References - Domain

InterPro IPR004365 (NA-bd_OB_tRNA.)
IPR004591 (Rfa1.)
IPR007199 (Rep_factor-A_N.)
IPR012340 (NA-bd_OB-fold.)
IPR013955 (Rep_factor-A_C.)
IPR031657 (REPA_OB_2.)
Pfam PF01336 (tRNA_anti-codon)
PF04057 (Rep-A_N)
PF08646 (Rep_fac-A_C)
PF16900 (REPA_OB_2)

Target Cross References - Structure

PDBe 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N More...
CREDO 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N More...