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Target Report Card

Target Name and Classification

Target ID CHEMBL1744526
Target Type SINGLE PROTEIN
Preferred Name Platelet glycoprotein 4
Synonyms CD36 | CD_antigen=CD36 | FAT | Fatty acid translocase | GP3B | GP4 | GPIIIB | GPIV | Glycoprotein IIIb | Leukocyte differentiation antigen CD36 | PAS IV | PAS-4 | Platelet collagen receptor | Platelet glycoprotein 4 | Platelet glycoprotein IV | Thrombospondin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Platelet glycoprotein 4 SINGLE PROTEIN P16671

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135218
Ensembl ENSG00000135218
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030666 (endocytic vesicle membrane)
GO:0031092 (platelet alpha granule membrane)
GO:0031526 (brush border membrane)
GO:0035579 (specific granule membrane)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO:0045177 (apical part of cell)
GO:0045335 (phagocytic vesicle)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0005041 (low-density lipoprotein receptor activity)
GO:0005044 (scavenger receptor activity)
GO:0005515 (protein binding)
GO:0008035 (high-density lipoprotein particle binding)
GO:0008289 (lipid binding)
GO:0030169 (low-density lipoprotein particle binding)
GO:0035325 (Toll-like receptor binding)
GO:0050431 (transforming growth factor beta binding)
GO:0070053 (thrombospondin receptor activity)
GO:0070892 (lipoteichoic acid receptor activity)
GO:0071813 (lipoprotein particle binding)
GO:0150025 (oxidised low-density lipoprotein particle receptor activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0002576 (platelet degranulation)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006629 (lipid metabolic process)
GO:0006898 (receptor-mediated endocytosis)
GO:0006910 (phagocytosis, recognition)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007596 (blood coagulation)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010886 (positive regulation of cholesterol storage)
GO:0010942 (positive regulation of cell death)
GO:0019216 (regulation of lipid metabolic process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019915 (lipid storage)
GO:0019934 (cGMP-mediated signaling)
GO:0030194 (positive regulation of blood coagulation)
GO:0030299 (intestinal cholesterol absorption)
GO:0030301 (cholesterol transport)
GO:0031623 (receptor internalization)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0033993 (response to lipid)
GO:0034121 (regulation of toll-like receptor signaling pathway)
GO:0034197 (triglyceride transport)
GO:0034381 (plasma lipoprotein particle clearance)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0035634 (response to stilbenoid)
GO:0038124 (toll-like receptor TLR6:TLR2 signaling pathway)
GO:0042953 (lipoprotein transport)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043277 (apoptotic cell clearance)
GO:0043312 (neutrophil degranulation)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043497 (regulation of protein heterodimerization activity)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0044539 (long-chain fatty acid import)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0050702 (interleukin-1 beta secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050892 (intestinal absorption)
GO:0050909 (sensory perception of taste)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0055096 (low-density lipoprotein particle mediated signaling)
GO:0060100 (positive regulation of phagocytosis, engulfment)
GO:0060907 (positive regulation of macrophage cytokine production)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070508 (cholesterol import)
GO:0070542 (response to fatty acid)
GO:0070543 (response to linoleic acid)
GO:0071221 (cellular response to bacterial lipopeptide)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0071447 (cellular response to hydroperoxide)
GO:0071726 (cellular response to diacyl bacterial lipopeptide)
GO:0097009 (energy homeostasis)
GO:0140052 (cellular response to oxidised low-density lipoprotein particle stimulus)
GO:0150024 (oxidised low-density lipoprotein particle clearance)
GO:1900227 (positive regulation of NLRP3 inflammasome complex assembly)
GO:1903428 (positive regulation of reactive oxygen species biosynthetic process)
GO:1904646 (cellular response to beta-amyloid)
GO:1990000 (amyloid fibril formation)
GO:2000121 (regulation of removal of superoxide radicals)
GO:2000334 (positive regulation of blood microparticle formation)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia CD36

Target Cross References - Protein

CGD Platelet glycoprotein IV deficiency
Human Protein Atlas ENSG00000135218
IntAct P16671
Open Targets ENSG00000135218
PharmGKB PA26212
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1236973 (Cross-presentation of particulate exogenous antigens (phagosomes).)
R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-168188 (Toll Like Receptor TLR6:TLR2 Cascade.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-3000471 (Scavenging by Class B Receptors.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-5602498 (MyD88 deficiency (TLR2/4).)
R-HSA-5603041 (IRAK4 deficiency (TLR2/4).)
R-HSA-5686938 (Regulation of TLR by endogenous ligand.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt D9IX66 D9IX67 D9IX68 D9IX69 P16671 Q13966 Q16093 Q8TCV7 Q9BPZ8 Q9BQC2 Q9BZM8 Q9BZN3 Q9BZN4 Q9BZN5

Target Cross References - Domain

InterPro IPR002159 (CD36_fam.)
IPR005428 (CD36/SCARB1/SNMP1.)
IPR033076 (CD36_chordates.)
Pfam PF01130 (CD36)

Target Cross References - Structure

PDBe 5LGD
CREDO 5LGD
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