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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1744525
Target Type SINGLE PROTEIN
Preferred Name Nicotinamide phosphoribosyltransferase
Synonyms NAMPT | NAmPRTase | Nampt | Nicotinamide phosphoribosyltransferase | PBEF | PBEF1 | Pre-B cell-enhancing factor | Pre-B-cell colony-enhancing factor 1 | Visfatin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nicotinamide phosphoribosyltransferase SINGLE PROTEIN P43490

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL190412 TEGLARINAD CHLORIDE Nicotinamide phosphoribosyltransferase inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105835
Ensembl ENSG00000105835
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030054 (cell junction)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004514 (nicotinate-nucleotide diphosphorylase (carboxylating) activity)
GO:0005125 (cytokine activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0042803 (protein homodimerization activity)
GO:0047280 (nicotinamide phosphoribosyltransferase activity)
GO Biological Process GO:0006769 (nicotinamide metabolic process)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0007623 (circadian rhythm)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0009435 (NAD biosynthetic process)
GO:0014070 (response to organic cyclic compound)
GO:0019363 (pyridine nucleotide biosynthetic process)
GO:0032922 (circadian regulation of gene expression)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0060612 (adipose tissue development)
Wikipedia Nicotinamide_phosphoribosyltransferase

Target Cross References - Protein

Human Protein Atlas ENSG00000105835
IntAct P43490
Open Targets ENSG00000105835
PharmGKB PA162396933
Reactome R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-197264 (Nicotinamide salvaging.)
UniProt A4D0Q9 A4D0R0 P43490 Q3KQV0 Q8WW95

Target Cross References - Domain

InterPro IPR002638 (Quinolinate_PRibosylTrfase_C.)
IPR007229 (Nic_PRibTrfase-Fam.)
IPR016471 (Nicotinamide_PRibTrfase.)
Pfam PF04095 (NAPRTase)

Target Cross References - Structure

PDBe 2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG More...
CREDO 2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG More...
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