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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1744522
Target Type SINGLE PROTEIN
Preferred Name Endothelial PAS domain-containing protein 1
Synonyms BHLHE73 | Basic-helix-loop-helix-PAS protein MOP2 | Class E basic helix-loop-helix protein 73 | EPAS-1 | EPAS1 | Endothelial PAS domain-containing protein 1 | HIF-1-alpha-like factor | HIF-2-alpha | HIF2-alpha | HIF2A | HLF | Hypoxia-inducible factor 2-alpha | MOP2 | Member of PAS protein 2 | PAS domain-containing protein 2 | PASD2 | bHLHe73
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Endothelial PAS domain-containing protein 1 SINGLE PROTEIN Q99814

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221345 Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116016
Ensembl ENSG00000116016
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0035035 (histone acetyltransferase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0001892 (embryonic placenta development)
GO:0001974 (blood vessel remodeling)
GO:0002027 (regulation of heart rate)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006979 (response to oxidative stress)
GO:0007005 (mitochondrion organization)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007601 (visual perception)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0030218 (erythrocyte differentiation)
GO:0030324 (lung development)
GO:0035019 (somatic stem cell population maintenance)
GO:0042415 (norepinephrine metabolic process)
GO:0043129 (surfactant homeostasis)
GO:0043619 (regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048469 (cell maturation)
GO:0048625 (myoblast fate commitment)
GO:0055072 (iron ion homeostasis)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0071456 (cellular response to hypoxia)
Wikipedia EPAS1

Target Cross References - Protein

CGD Erthyrocytosis, familial 4
Human Protein Atlas ENSG00000116016
IntAct Q99814
Open Targets ENSG00000116016
PharmGKB PA27809
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1234162 (Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.)
R-HSA-1234176 (Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.)
R-HSA-452723 (Transcriptional regulation of pluripotent stem cells.)
R-HSA-8849473 (PTK6 Expression.)
UniProt Q86VA2 Q99630 Q99814

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001067 (Nuc_translocat.)
IPR001610 (PAC.)
IPR011598 (bHLH_dom.)
IPR013767 (PAS_fold.)
IPR014887 (HIF-1_TAD_C.)
IPR021537 (HIF_alpha_subunit.)
Pfam PF00989 (PAS)
PF08778 (HIF-1a_CTAD)
PF11413 (HIF-1)

Target Cross References - Structure

PDBe 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2
CREDO 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2
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