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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743316
Target Type SINGLE PROTEIN
Preferred Name UDP-glucuronosyltransferase 1-6
Synonyms GNT1 | Phenol-metabolizing UDP-glucuronosyltransferase | UDP-glucuronosyltransferase 1-6 | UDP-glucuronosyltransferase 1-F | UDP-glucuronosyltransferase 1A6 | UDPGT 1-6 | UGT-1F | UGT1 | UGT1*6 | UGT1-06 | UGT1.6 | UGT1A6 | UGT1F
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
UDP-glucuronosyltransferase 1-6 SINGLE PROTEIN P19224

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167165
Ensembl ENSG00000167165
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001972 (retinoic acid binding)
GO:0015020 (glucuronosyltransferase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0016758 (transferase activity, transferring hexosyl groups)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0008152 (metabolic process)
GO:0009813 (flavonoid biosynthetic process)
GO:0017144 (drug metabolic process)
GO:0045922 (negative regulation of fatty acid metabolic process)
GO:0052695 (cellular glucuronidation)
GO:0052696 (flavonoid glucuronidation)
GO:0052697 (xenobiotic glucuronidation)
GO:1904224 (negative regulation of glucuronosyltransferase activity)
GO:2001030 (negative regulation of cellular glucuronidation)
Wikipedia UGT1A6

Target Cross References - Protein

Human Protein Atlas ENSG00000167165
IntAct P19224
Open Targets ENSG00000167165
PharmGKB PA37181
Reactome R-HSA-156588 (Glucuronidation.)
UniProt A6NKK6 B8K289 P19224 Q96TE7

Target Cross References - Domain

InterPro IPR002213 (UDP_glucos_trans.)
Pfam PF00201 (UDPGT)
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