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Target Report Card

Target Name and Classification

Target ID CHEMBL1743186
Preferred Name Microsomal glutathione S-transferase 3
Synonyms MGST3 | Microsomal GST-3 | Microsomal GST-III | Microsomal glutathione S-transferase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Microsomal glutathione S-transferase 3 SINGLE PROTEIN O14880

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143198
Ensembl ENSG00000143198
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004464 (leukotriene-C4 synthase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0010243 (response to organonitrogen compound)
GO:0019370 (leukotriene biosynthetic process)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia MGST3

Target Cross References - Protein

Human Protein Atlas ENSG00000143198
IntAct O14880
Open Targets ENSG00000143198
PharmGKB PA30793
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
UniProt B2R592 O14880 Q6ICN4

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR023352 (MAPEG-like_dom_sf.)
Pfam PF01124 (MAPEG)