ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1743185
Target Type SINGLE PROTEIN
Preferred Name Microsomal glutathione S-transferase 2
Synonyms GST2 | MGST2 | Microsomal GST-2 | Microsomal GST-II | Microsomal glutathione S-transferase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Microsomal glutathione S-transferase 2 SINGLE PROTEIN Q99735

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000085871
Ensembl ENSG00000085871
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004464 (leukotriene-C4 synthase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0008047 (enzyme activator activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006691 (leukotriene metabolic process)
GO:0006750 (glutathione biosynthetic process)
GO:0006805 (xenobiotic metabolic process)
GO:0010243 (response to organonitrogen compound)
GO:0019370 (leukotriene biosynthetic process)
GO:0032496 (response to lipopolysaccharide)
GO:0043085 (positive regulation of catalytic activity)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia MGST2

Target Cross References - Protein

Human Protein Atlas ENSG00000085871
IntAct Q99735
Open Targets ENSG00000085871
PharmGKB PA30792
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
UniProt D6RBB5 Q7Z5B8 Q99735

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR001446 (5_LipOase_AP.)
IPR018295 (FLAP/GST2/LTC4S_CS.)
IPR023352 (MAPEG-like_dom.)
Pfam PF01124 (MAPEG)
spacer
spacer