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Target Report Card

Target Name and Classification

Target ID CHEMBL1743184
Preferred Name Microsomal glutathione S-transferase 1
Synonyms GST12 | MGST | MGST1 | Microsomal GST-1 | Microsomal GST-I | Microsomal glutathione S-transferase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Microsomal glutathione S-transferase 1 SINGLE PROTEIN P10620

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008394
Ensembl ENSG00000008394
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0005778 (peroxisomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043295 (glutathione binding)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0010243 (response to organonitrogen compound)
GO:0032496 (response to lipopolysaccharide)
GO:0033327 (Leydig cell differentiation)
GO:0042493 (response to drug)
GO:0055114 (oxidation-reduction process)
GO:0070207 (protein homotrimerization)
GO:0071449 (cellular response to lipid hydroperoxide)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia Microsomal_glutathione_S-transferase_1

Target Cross References - Protein

Human Protein Atlas ENSG00000008394
IntAct P10620
Open Targets ENSG00000008394
PharmGKB PA30791
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8K533 G5EA53 P10620

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR023352 (MAPEG-like_dom.)
Pfam PF01124 (MAPEG)