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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743183
Target Type SINGLE PROTEIN
Preferred Name Leukotriene C4 synthase
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Leukotriene C4 synthase SINGLE PROTEIN Q16873

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213316
Ensembl ENSG00000213316
GO Cellular Component GO:0005640 (nuclear outer membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016021 (integral component of membrane)
GO:0005635 (nuclear envelope)
GO:0005783 (endoplasmic reticulum)
GO Molecular Function GO:0004602 (glutathione peroxidase activity)
GO:0008047 (enzyme activator activity)
GO:0043295 (glutathione binding)
GO:0004364 (glutathione transferase activity)
GO:0008289 (lipid binding)
GO:0004464 (leukotriene-C4 synthase activity)
GO Biological Process GO:0019369 (arachidonic acid metabolic process)
GO:0042493 (response to drug)
GO:0044281 (small molecule metabolic process)
GO:0019372 (lipoxygenase pathway)
GO:0010035 (response to inorganic substance)
GO:0019370 (leukotriene biosynthetic process)
GO:0006691 (leukotriene metabolic process)
GO:0071299 (cellular response to vitamin A)
GO:2001300 (lipoxin metabolic process)
GO:0048678 (response to axon injury)
GO:0055114 (oxidation-reduction process)
GO:0071222 (cellular response to lipopolysaccharide)
Wikipedia Leukotriene_C4_synthase

Target Cross References - Protein

CGD Asthma, aspirin-induced, susceptibility to
Human Protein Atlas ENSG00000213316
Guide to Pharmacology 1391 (Leukotriene C4 synthase)
PharmGKB PA235
UniProt Q9UD18 Q8N6P0 Q16873 Q9UC73

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR023352 (MAPEG-like_dom.)
IPR001446 (5_LipOase_AP.)
IPR018295 (FLAP/GST2/LTC4S_CS.)
Pfam PF01124 (MAPEG)

Target Cross References - Structure

PDBe 2UUH 4JRZ 2PNO 3PCV 3HKK 4J7T 4JCZ 4JC7 2UUI 3B29 3LEO 4J7Y
CREDO 2UUH 4JRZ 2PNO 3PCV 3HKK 4J7T 4JCZ 4JC7 2UUI 3B29 3LEO 4J7Y
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