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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743183
Target Type SINGLE PROTEIN
Preferred Name Leukotriene C4 synthase
Synonyms LTC4 synthase | LTC4S | Leukotriene C4 synthase | Leukotriene-C(4) synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Leukotriene C4 synthase SINGLE PROTEIN Q16873

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213316 ENSG00000283887
Ensembl ENSG00000213316 ENSG00000283887
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005640 (nuclear outer membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004464 (leukotriene-C4 synthase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0005515 (protein binding)
GO:0008047 (enzyme activator activity)
GO:0008289 (lipid binding)
GO:0016829 (lyase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006691 (leukotriene metabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0019372 (lipoxygenase pathway)
GO:0043085 (positive regulation of catalytic activity)
GO:0098869 (cellular oxidant detoxification)
GO:2001301 (lipoxin biosynthetic process)
Wikipedia Leukotriene_C4_synthase

Target Cross References - Protein

CGD Asthma, aspirin-induced, susceptibility to
Human Protein Atlas ENSG00000213316 ENSG00000283887
IntAct Q16873
Guide to Pharmacology 1391
Open Targets ENSG00000213316 ENSG00000283887
PharmGKB PA235
Reactome R-HSA-2142688 (Synthesis of 5-eicosatetraenoic acids.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2142700 (Synthesis of Lipoxins (LX).)
UniProt Q16873 Q8N6P0 Q9UC73 Q9UD18

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR001446 (5_LipOase_AP.)
IPR018295 (FLAP/GST2/LTC4S_CS.)
IPR023352 (MAPEG-like_dom_sf.)
Pfam PF01124 (MAPEG)

Target Cross References - Structure

PDBe 2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9
CREDO 2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9
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