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Target Report Card

Target Name and Classification

Target ID CHEMBL1743129
Target Type SINGLE PROTEIN
Preferred Name Multidrug resistance protein 3
Synonyms ABCB4 | ATP-binding cassette sub-family B member 4 | MDR3 | Multidrug resistance protein 3 | P-glycoprotein 3 | PGY3 | Phosphatidylcholine translocator ABCB4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcb subfamily

Target Components

Component Description Relationship Accession
Phosphatidylcholine translocator ABCB4 SINGLE PROTEIN P21439

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005471
Ensembl ENSG00000005471
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030136 (clathrin-coated vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0045121 (membrane raft)
GO:0046581 (intercellular canaliculus)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005548 (phospholipid transporter activity)
GO:0008525 (phosphatidylcholine transporter activity)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0090554 (phosphatidylcholine-translocating ATPase activity)
GO Biological Process GO:0002481 (antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)
GO:0002485 (antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)
GO:0002489 (antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)
GO:0002591 (positive regulation of antigen processing and presentation of peptide antigen via MHC class I)
GO:0006629 (lipid metabolic process)
GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0006869 (lipid transport)
GO:0032376 (positive regulation of cholesterol transport)
GO:0032782 (bile acid secretion)
GO:0042493 (response to drug)
GO:0042908 (xenobiotic transport)
GO:0045332 (phospholipid translocation)
GO:0055085 (transmembrane transport)
GO:0055088 (lipid homeostasis)
GO:0061092 (positive regulation of phospholipid translocation)
GO:1901557 (response to fenofibrate)
GO:1903413 (cellular response to bile acid)
GO:2001140 (positive regulation of phospholipid transport)
Wikipedia ABCB4

Target Cross References - Protein

CGD Cholestasis, progressive familial intrahepatic 3; Low phospholipid-associated cholelithiasis 1; Cholestasis, oral contraceptives induced; Cholestasis, familial intrahepatic, of pregnancy; Gallbladder disease 1
Human Protein Atlas ENSG00000005471
IntAct P21439
Open Targets ENSG00000005471
PharmGKB PA268
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt A0A2V7 A4D1D3 A4D1D4 A4D1D5 D6W5P3 D6W5P4 P21439 Q14813

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
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