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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743128
Target Type SINGLE PROTEIN
Preferred Name Multidrug resistance-associated protein 4
Synonyms ABCC4 | ATP-binding cassette sub-family C member 4 | MOAT-B | MRP/cMOAT-related ABC transporter | MRP4 | Multi-specific organic anion transporter B | Multidrug resistance-associated protein 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Multidrug resistance-associated protein 4 SINGLE PROTEIN O15439

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125257
Ensembl ENSG00000125257
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031088 (platelet dense granule membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0015662 (ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism)
GO:0016404 (15-hydroxyprostaglandin dehydrogenase (NAD+) activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0043225 (anion transmembrane-transporting ATPase activity)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0006810 (transport)
GO:0008150 (biological_process)
GO:0032310 (prostaglandin secretion)
GO:0034220 (ion transmembrane transport)
GO:0042384 (cilium assembly)
GO:0055085 (transmembrane transport)
GO:0055114 (oxidation-reduction process)
GO:0098656 (anion transmembrane transport)
Wikipedia ABCC4

Target Cross References - Protein

Human Protein Atlas ENSG00000125257
IntAct O15439
Guide to Pharmacology 782
Open Targets ENSG00000125257
PharmGKB PA397
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt A9Z1Z7 B7Z3Q7 O15439 Q8IVZ4 Q8IZN6 Q8NEW8 Q9Y6J2

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR030240 (ABCC4.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
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