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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743127
Preferred Name Multidrug and toxin extrusion protein 2
Synonyms Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | Multidrug and toxin extrusion protein 2 | SLC47A2 | Solute carrier family 47 member 2 | hMATE-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc47 family of multidrug and toxin extrusion transporters

Target Components

Component Description Relationship Accession
Multidrug and toxin extrusion protein 2 SINGLE PROTEIN Q86VL8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180638
Ensembl ENSG00000180638
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0015238 (drug transmembrane transporter activity)
GO:0015297 (antiporter activity)
GO:0015307 (drug:proton antiporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0046618 (drug export)
GO:0055085 (transmembrane transport)
Wikipedia SLC47A2

Target Cross References - Protein

Human Protein Atlas ENSG00000180638
Guide to Pharmacology 1217
Open Targets ENSG00000180638
PharmGKB PA162403847
Reactome R-HSA-425366 (Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.)
UniProt A0JBX9 A0P8Z7 Q63HJ9 Q86VL8 Q8IV44 Q96NA1

Target Cross References - Domain

InterPro IPR002528 (MATE_fam.)
Pfam PF01554 (MatE)