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Target Report Card

Target Name and Classification

Target ID CHEMBL1743126
Preferred Name Multidrug and toxin extrusion protein 1
Synonyms MATE-1 | MATE1 | Multidrug and toxin extrusion protein 1 | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc47 family of multidrug and toxin extrusion transporters

Target Components

Component Description Relationship Accession
Multidrug and toxin extrusion protein 1 SINGLE PROTEIN Q96FL8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142494
Ensembl ENSG00000142494
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031988 (membrane-bounded vesicle)
GO Molecular Function GO:0005451 (monovalent cation:proton antiporter activity)
GO:0015238 (drug transmembrane transporter activity)
GO:0015297 (antiporter activity)
GO:0015307 (drug:proton antiporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0015695 (organic cation transport)
GO:0015893 (drug transport)
GO:0046618 (drug export)
GO:0055085 (transmembrane transport)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia SLC47A1

Target Cross References - Protein

Human Protein Atlas ENSG00000142494
IntAct Q96FL8
Guide to Pharmacology 1216
Open Targets ENSG00000142494
PharmGKB PA162403808
Reactome R-HSA-425366 (Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.)
UniProt Q53HF5 Q6PD77 Q86VL4 Q96FL8 Q9NVA3

Target Cross References - Domain

InterPro IPR002528 (MATE_fam.)
Pfam PF01554 (MatE)