ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1743123
Preferred Name Solute carrier organic anion transporter family member 1A2
Synonyms OATP | OATP-1 | OATP-A | OATP1 | OATP1A2 | Organic anion-transporting polypeptide 1 | SLC21A3 | SLCO1A2 | Sodium-independent organic anion transporter | Solute carrier family 21 member 3 | Solute carrier organic anion transporter family member 1A2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc21/slco family of organic anion transporting polypeptides

Target Components

Component Description Relationship Accession
Solute carrier organic anion transporter family member 1A2 SINGLE PROTEIN P46721

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084453
Ensembl ENSG00000084453
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015125 (bile acid transmembrane transporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0008206 (bile acid metabolic process)
GO:0015711 (organic anion transport)
GO:0015721 (bile acid and bile salt transport)
GO:0043252 (sodium-independent organic anion transport)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
Wikipedia SLCO1A2

Target Cross References - Protein

Human Protein Atlas ENSG00000084453
IntAct P46721
Guide to Pharmacology 1219
Open Targets ENSG00000084453
PharmGKB PA328
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-879518 (Transport of organic anions.)
UniProt P46721 Q9UGP7 Q9UL38

Target Cross References - Domain

InterPro IPR002350 (Kazal_dom.)
IPR004156 (OA_transporter.)
IPR020846 (MFS_dom.)
Pfam PF03137 (OATP)
PF07648 (Kazal_2)