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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743122
Preferred Name Solute carrier family 22 member 2
Synonyms OCT2 | Organic cation transporter 2 | SLC22A2 | Solute carrier family 22 member 2 | hOCT2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc22 family of organic cation and anion transporters

Target Components

Component Description Relationship Accession
Solute carrier family 22 member 2 SINGLE PROTEIN O15244

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112499
Ensembl ENSG00000112499
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0005329 (dopamine transmembrane transporter activity)
GO:0015101 (organic cation transmembrane transporter activity)
GO:0015220 (choline transmembrane transporter activity)
GO:0015651 (quaternary ammonium group transmembrane transporter activity)
GO Biological Process GO:0015872 (dopamine transport)
GO:0044281 (small molecule metabolic process)
GO:0055085 (transmembrane transport)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0007268 (synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0007589 (body fluid secretion)
GO:0015695 (organic cation transport)
GO:0015871 (choline transport)
GO:0072488 (ammonium transmembrane transport)
GO:0015697 (quaternary ammonium group transport)
GO:0006855 (drug transmembrane transport)
Wikipedia SLC22A2

Target Cross References - Protein

Human Protein Atlas ENSG00000112499
IntAct O15244
Guide to Pharmacology 1020 (Organic cation transporter 2)
PharmGKB PA331
UniProt O15244 Q9NQB9 Q8NG62 Q5T7Q6 Q6PIQ8

Target Cross References - Domain

InterPro IPR005829 (Sugar_transporter_CS.)
IPR004749 (Orgcat_transp/SVOP.)
IPR020846 (MFS_dom.)
IPR005828 (MFS_sugar_transport_like.)
Pfam PF00083 (Sugar_tr)