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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1743121
Target Type SINGLE PROTEIN
Preferred Name Solute carrier organic anion transporter family member 1B3
Synonyms LST-2 | LST2 | Liver-specific organic anion transporter 2 | OATP-8 | OATP1B3 | OATP8 | Organic anion transporter 8 | Organic anion-transporting polypeptide 8 | SLC21A8 | SLCO1B3 | Solute carrier family 21 member 8 | Solute carrier organic anion transporter family member 1B3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc21/slco family of organic anion transporting polypeptides

Target Components

Component Description Relationship Accession
Solute carrier organic anion transporter family member 1B3 SINGLE PROTEIN Q9NPD5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111700
Ensembl ENSG00000111700
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015125 (bile acid transmembrane transporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0008206 (bile acid metabolic process)
GO:0015711 (organic anion transport)
GO:0015721 (bile acid and bile salt transport)
GO:0043252 (sodium-independent organic anion transport)
Wikipedia SLCO1B3

Target Cross References - Protein

CGD Hyperbilirubinemia, Rotor type, digenic
Human Protein Atlas ENSG00000111700
Guide to Pharmacology 1221
Open Targets ENSG00000111700
PharmGKB PA35844
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-879518 (Transport of organic anions.)
UniProt E7EMT8 Q5JAR4 Q9NPD5

Target Cross References - Domain

InterPro IPR002350 (Kazal_dom.)
IPR004156 (OA_transporter.)
IPR020846 (MFS_dom.)
Pfam PF03137 (OATP)
PF07648 (Kazal_2)
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