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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741309
Target Type SINGLE PROTEIN
Preferred Name Osteopontin
Synonyms BNSP | Bone sialoprotein 1 | Nephropontin | OPN | Osteopontin | SPP-1 | SPP1 | Secreted phosphoprotein 1 | Urinary stone protein | Uropontin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Osteopontin SINGLE PROTEIN P10451

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109530 ASK-8007 Osteopontin inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118785
Ensembl ENSG00000118785
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005794 (Golgi apparatus)
GO:0031982 (vesicle)
GO:0042995 (cell projection)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005515 (protein binding)
GO:0050840 (extracellular matrix binding)
GO Biological Process GO:0001503 (ossification)
GO:0001649 (osteoblast differentiation)
GO:0006710 (androgen catabolic process)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007566 (embryo implantation)
GO:0010033 (response to organic substance)
GO:0010469 (regulation of receptor activity)
GO:0022617 (extracellular matrix disassembly)
GO:0030154 (cell differentiation)
GO:0030198 (extracellular matrix organization)
GO:0031214 (biomineral tissue development)
GO:0033280 (response to vitamin D)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0045780 (positive regulation of bone resorption)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046697 (decidualization)
GO:0048545 (response to steroid hormone)
GO:0048685 (negative regulation of collateral sprouting of intact axon in response to injury)
GO:0071394 (cellular response to testosterone stimulus)
GO:2000866 (positive regulation of estradiol secretion)
Wikipedia Osteopontin

Target Cross References - Protein

Human Protein Atlas ENSG00000118785
IntAct P10451
Open Targets ENSG00000118785
PharmGKB PA36085
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-186797 (Signaling by PDGF.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-8949275 (RUNX3 Regulates Immune Response and Cell Migration.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
UniProt B2RDA1 P10451 Q15681 Q15682 Q15683 Q4W597 Q567T5 Q8NBK2 Q96IZ1

Target Cross References - Domain

InterPro IPR002038 (Osteopontin.)
IPR019841 (Osteopontin_CS.)
Pfam PF00865 (Osteopontin)

Target Cross References - Structure

PDBe 3CXD 3DSF
CREDO 3CXD 3DSF
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