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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741305
Target Type SINGLE PROTEIN
Preferred Name Interleukin-18
Synonyms IFN-gamma-inducing factor | IGIF | IL-1 gamma | IL-18 | IL18 | IL1F4 | Iboctadekin | Interferon gamma-inducing factor | Interleukin-1 gamma | Interleukin-18
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Interleukin-18 SINGLE PROTEIN Q14116

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109606 GSK-1070806 Interleukin-18 inhibitor 2 PubMed
CHEMBL2109604 MEDI-2338 Interleukin-18 cross-linking agent 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150782
Ensembl ENSG00000150782
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005515 (protein binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001525 (angiogenesis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007267 (cell-cell signaling)
GO:0008283 (cell proliferation)
GO:0010469 (regulation of receptor activity)
GO:0010628 (positive regulation of gene expression)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030101 (natural killer cell activation)
GO:0030155 (regulation of cell adhesion)
GO:0030431 (sleep)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032148 (activation of protein kinase B activity)
GO:0032609 (interferon-gamma production)
GO:0032635 (interleukin-6 production)
GO:0032725 (positive regulation of granulocyte macrophage colony-stimulating factor production)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032819 (positive regulation of natural killer cell proliferation)
GO:0034105 (positive regulation of tissue remodeling)
GO:0035655 (interleukin-18-mediated signaling pathway)
GO:0035744 (T-helper 1 cell cytokine production)
GO:0042033 (chemokine biosynthetic process)
GO:0042088 (T-helper 1 type immune response)
GO:0042092 (type 2 immune response)
GO:0042094 (interleukin-2 biosynthetic process)
GO:0042095 (interferon-gamma biosynthetic process)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042119 (neutrophil activation)
GO:0042231 (interleukin-13 biosynthetic process)
GO:0042253 (granulocyte macrophage colony-stimulating factor biosynthetic process)
GO:0042267 (natural killer cell mediated cytotoxicity)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042632 (cholesterol homeostasis)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050729 (positive regulation of inflammatory response)
GO:0051142 (positive regulation of NK T cell proliferation)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0070328 (triglyceride homeostasis)
GO:0071407 (cellular response to organic cyclic compound)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
Wikipedia Interleukin_18

Target Cross References - Protein

Human Protein Atlas ENSG00000150782
IntAct Q14116
Open Targets ENSG00000150782
PharmGKB PA29802
Reactome R-HSA-448706 (Interleukin-1 processing.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-9012546 (Interleukin-18 signaling.)
UniProt O75599 Q14116 Q6FGY3 Q6WWJ7

Target Cross References - Domain

InterPro IPR000975 (IL-1_fam.)
IPR008996 (IL1/FGF.)
IPR015529 (IL-18.)
Pfam PF00340 (IL1)

Target Cross References - Structure

PDBe 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
CREDO 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
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