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Target Report Card

Target Name and Classification

Target ID CHEMBL1741208
Preferred Name NACHT, LRR and PYD domains-containing protein 3
Synonyms Angiotensin/vasopressin receptor AII/AVP-like | C1orf7 | CIAS1 | CLR1.1 | Caterpiller protein 1.1 | Cold autoinflammatory syndrome 1 protein | Cryopyrin | NACHT, LRR and PYD domains-containing protein 3 | NALP3 | NLRP3 | PYPAF1 | PYRIN-containing APAF1-like protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
NACHT, LRR and PYD domains-containing protein 3 SINGLE PROTEIN Q96P20

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162711
Ensembl ENSG00000162711
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0042834 (peptidoglycan binding)
GO Biological Process GO:0006917 (induction of apoptosis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0009595 (detection of biotic stimulus)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0042347 (negative regulation of NF-kappaB import into nucleus)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0051259 (protein oligomerization)
Wikipedia NALP3

Target Cross References - Protein

CGD Chronic Infantile Neurologic Cutaneous Articular (CINCA) syndrome; Neonatal Onset Multisystem Inflammatory Disease (NOMID); Muckle-Wells syndrome
Human Protein Atlas ENSG00000162711
Guide to Pharmacology 1770 (NLRP3)
PharmGKB PA26512
UniProt B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 Q96P20

Target Cross References - Domain

InterPro IPR003590 (Leu-rich_rpt_RNase_inh_sub-typ.)
IPR004020 (Pyrin.)
IPR007111 (NACHT_NTPase.)
IPR011029 (DEATH-like.)
Pfam PF02758 (PAAD_DAPIN)