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Target Report Card

Target Name and Classification

Target ID CHEMBL1741208
Target Type SINGLE PROTEIN
Preferred Name NACHT, LRR and PYD domains-containing protein 3
Synonyms Angiotensin/vasopressin receptor AII/AVP-like | C1orf7 | CIAS1 | CLR1.1 | Caterpiller protein 1.1 | Cold-induced autoinflammatory syndrome 1 protein | Cryopyrin | NACHT, LRR and PYD domains-containing protein 3 | NALP3 | NLRP3 | PYPAF1 | PYRIN-containing APAF1-like protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
NACHT, LRR and PYD domains-containing protein 3 SINGLE PROTEIN Q96P20

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162711
Ensembl ENSG00000162711
GO Cellular Component GO:0005829 (cytosol)
GO:0072559 (NLRP3 inflammasome complex)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO Molecular Function GO:0043565 (sequence-specific DNA binding)
GO:0042834 (peptidoglycan binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0009595 (detection of biotic stimulus)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0044546 (NLRP3 inflammasome complex assembly)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0007165 (signal transduction)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0006952 (defense response)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0002830 (positive regulation of type 2 immune response)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006954 (inflammatory response)
GO:2000553 (positive regulation of T-helper 2 cell cytokine production)
GO:0006915 (apoptotic process)
GO:0032621 (interleukin-18 production)
GO:0035872 (nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)
GO:0045087 (innate immune response)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0032611 (interleukin-1 beta production)
GO:0050701 (interleukin-1 secretion)
GO:0050713 (negative regulation of interleukin-1 beta secretion)
GO:0050728 (negative regulation of inflammatory response)
GO:0042347 (negative regulation of NF-kappaB import into nucleus)
GO:0051607 (defense response to virus)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0071222 (cellular response to lipopolysaccharide)
Wikipedia NALP3

Target Cross References - Protein

CGD Chronic Infantile Neurologic Cutaneous Articular (CINCA) syndrome; Neonatal Onset Multisystem Inflammatory Disease (NOMID); Muckle-Wells syndrome
Human Protein Atlas ENSG00000162711
IntAct Q96P20
Guide to Pharmacology 1770 (NLRP3)
PharmGKB PA26512
UniProt B7ZKT2 Q17RS2 Q5JQS9 Q8TCW0 B7ZKT3 Q6TG35 Q5JQS8 Q96P20 O75434 Q59H68 Q8TEU9 Q8WXH9

Target Cross References - Domain

InterPro IPR004020 (DAPIN.)
IPR007111 (NACHT_NTPase.)
IPR029495 (NATCH-assoc.)
IPR027417 (P-loop_NTPase.)
IPR011029 (DEATH-like_dom.)
IPR003590 (Leu-rich_rpt_RNase_inh_sub-typ.)
Pfam PF02758 (PYRIN)
PF14484 (FISNA)

Target Cross References - Structure

PDBe 3QF2
CREDO 3QF2
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