ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1741208
Target Type SINGLE PROTEIN
Preferred Name NACHT, LRR and PYD domains-containing protein 3
Synonyms Angiotensin/vasopressin receptor AII/AVP-like | C1orf7 | CIAS1 | CLR1.1 | Caterpiller protein 1.1 | Cold-induced autoinflammatory syndrome 1 protein | Cryopyrin | NACHT, LRR and PYD domains-containing protein 3 | NALP3 | NLRP3 | PYPAF1 | PYRIN-containing APAF1-like protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
NACHT, LRR and PYD domains-containing protein 3 SINGLE PROTEIN Q96P20

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162711
Ensembl ENSG00000162711
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0061702 (inflammasome complex)
GO:0072559 (NLRP3 inflammasome complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0042834 (peptidoglycan binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0002830 (positive regulation of type 2 immune response)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0009595 (detection of biotic stimulus)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032611 (interleukin-1 beta production)
GO:0032621 (interleukin-18 production)
GO:0032736 (positive regulation of interleukin-13 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032754 (positive regulation of interleukin-5 production)
GO:0042347 (negative regulation of NF-kappaB import into nucleus)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0044546 (NLRP3 inflammasome complex assembly)
GO:0045087 (innate immune response)
GO:0045630 (positive regulation of T-helper 2 cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050701 (interleukin-1 secretion)
GO:0050713 (negative regulation of interleukin-1 beta secretion)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0050727 (regulation of inflammatory response)
GO:0050728 (negative regulation of inflammatory response)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0051607 (defense response to virus)
GO:0071222 (cellular response to lipopolysaccharide)
GO:2000321 (positive regulation of T-helper 17 cell differentiation)
GO:2000553 (positive regulation of T-helper 2 cell cytokine production)
Wikipedia NALP3

Target Cross References - Protein

CGD Chronic Infantile Neurologic Cutaneous Articular (CINCA) syndrome; Neonatal Onset Multisystem Inflammatory Disease (NOMID); Muckle-Wells syndrome
Human Protein Atlas ENSG00000162711
IntAct Q96P20
Guide to Pharmacology 1770
Open Targets ENSG00000162711
PharmGKB PA26512
Reactome R-HSA-5689901 (Metalloprotease DUBs.)
R-HSA-844456 (The NLRP3 inflammasome.)
UniProt A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 Q96P20

Target Cross References - Domain

InterPro IPR001611 (Leu-rich_rpt.)
IPR004020 (DAPIN.)
IPR007111 (NACHT_NTPase.)
IPR011029 (DEATH-like_dom.)
IPR027417 (P-loop_NTPase.)
IPR029495 (NACHT-assoc.)
IPR032675 (L_dom-like.)
Pfam PF02758 (PYRIN)
PF13516 (LRR_6)
PF14484 (FISNA)

Target Cross References - Structure

PDBe 3QF2
CREDO 3QF2
spacer
spacer