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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741193
Target Type SINGLE PROTEIN
Preferred Name Chromobox protein homolog 1
Synonyms CBX | CBX1 | Chromobox protein homolog 1 | HP1 beta | HP1Hsbeta | Heterochromatin protein 1 homolog beta | Heterochromatin protein p25 | M31 | Modifier 1 protein | p25beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > chromodomain

Target Components

Component Description Relationship Accession
Chromobox protein homolog 1 SINGLE PROTEIN P83916

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108468
Ensembl ENSG00000108468
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0000785 (chromatin)
GO:0001939 (female pronucleus)
GO:0001940 (male pronucleus)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005720 (nuclear heterochromatin)
GO:0005721 (pericentric heterochromatin)
GO:0005819 (spindle)
GO:0010369 (chromocenter)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:1990226 (histone methyltransferase binding)
GO Biological Process GO:0045892 (negative regulation of transcription, DNA-templated)
Wikipedia CBX1

Target Cross References - Protein

Human Protein Atlas ENSG00000108468
IntAct P83916
Open Targets ENSG00000108468
PharmGKB PA26126
UniProt P23197 P83916

Target Cross References - Domain

InterPro IPR000953 (Chromo/chromo_shadow_dom.)
IPR008251 (Chromo_shadow_dom.)
IPR016197 (Chromodomain-like.)
IPR017984 (Chromo_dom_subgr.)
IPR023779 (Chromodomain_CS.)
IPR023780 (Chromo_domain.)
Pfam PF00385 (Chromo)
PF01393 (Chromo_shadow)

Target Cross References - Structure

PDBe 2FMM 3F2U 3Q6S 5T1G
CREDO 2FMM 3F2U 3Q6S 5T1G
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