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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741191
Preferred Name SUMO-conjugating enzyme UBC9
Synonyms RING-type E3 SUMO transferase UBC9 | SUMO-conjugating enzyme UBC9 | SUMO-protein ligase | UBC9 | UBCE9 | UBE2I | Ubiquitin carrier protein 9 | Ubiquitin carrier protein I | Ubiquitin-conjugating enzyme E2 I | Ubiquitin-protein ligase I | p18
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
SUMO-conjugating enzyme UBC9 SINGLE PROTEIN P63279

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103275
Ensembl ENSG00000103275
GO Cellular Component GO:0000795 (synaptonemal complex)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO:1990234 (transferase complex)
GO:1990356 (sumoylated E2 ligase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0016874 (ligase activity)
GO:0019789 (SUMO transferase activity)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0043398 (HLH domain binding)
GO:0044822 (poly(A) RNA binding)
GO:0061630 (ubiquitin protein ligase activity)
GO:0061656 (SUMO conjugating enzyme activity)
GO:0071535 (RING-like zinc finger domain binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006464 (cellular protein modification process)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007067 (mitotic nuclear division)
GO:0016032 (viral process)
GO:0016925 (protein sumoylation)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051301 (cell division)
GO:0070911 (global genome nucleotide-excision repair)
GO:1903755 (positive regulation of SUMO transferase activity)
Wikipedia UBE2I

Target Cross References - Protein

Human Protein Atlas ENSG00000103275
IntAct P63279
Open Targets ENSG00000103275
PharmGKB PA37134
Reactome R-HSA-1221632 (Meiotic synapsis.)
R-HSA-3065678 (SUMO is transferred from E1 to E2 (UBE2I, UBC9).)
R-HSA-3108214 (SUMOylation of DNA damage response and repair proteins.)
R-HSA-3232118 (SUMOylation of transcription factors.)
R-HSA-4551638 (SUMOylation of chromatin organization proteins.)
R-HSA-4570464 (SUMOylation of RNA binding proteins.)
R-HSA-4615885 (SUMOylation of DNA replication proteins.)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-8866904 (Negative regulation of activity of TFAP2 (AP-2) family transcription factors.)
UniProt D3DU69 P50550 P63279 Q15698 Q59GX1 Q86VB3

Target Cross References - Domain

InterPro IPR000608 (UBQ-conjugat_E2.)
IPR016135 (UBQ-conjugating_enzyme/RWD.)
IPR023313 (UBQ-conjugating_AS.)
IPR027230 (Ubc9.)
Pfam PF00179 (UQ_con)

Target Cross References - Structure

PDBe 1A3S 1KPS 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X More...
CREDO 1A3S 1KPS 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X More...