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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741186
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor ROR-gamma
Synonyms NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group f > nuclear hormone receptor subfamily 1 group f member 3

Target Components

Component Description Relationship Accession
Nuclear receptor ROR-gamma SINGLE PROTEIN P51449

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545357 JTE-151 Nuclear receptor ROR-gamma antagonist 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143365
Ensembl ENSG00000143365
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008142 (oxysterol binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0098531 (transcription factor activity, direct ligand regulated sequence-specific DNA binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006805 (xenobiotic metabolic process)
GO:0007275 (multicellular organism development)
GO:0007623 (circadian rhythm)
GO:0010906 (regulation of glucose metabolic process)
GO:0019218 (regulation of steroid metabolic process)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032922 (circadian regulation of gene expression)
GO:0036315 (cellular response to sterol)
GO:0042093 (T-helper cell differentiation)
GO:0042753 (positive regulation of circadian rhythm)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045598 (regulation of fat cell differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048511 (rhythmic process)
GO:0048535 (lymph node development)
GO:0048541 (Peyer's patch development)
GO:0060612 (adipose tissue development)
GO:0060850 (regulation of transcription involved in cell fate commitment)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0072539 (T-helper 17 cell differentiation)
Wikipedia RAR-related_orphan_receptor_gamma

Target Cross References - Protein

Human Protein Atlas ENSG00000143365
IntAct P51449
Open Targets ENSG00000143365
PharmGKB PA34632
Pharos P51449 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P51449 Q5SZR9 Q8N5V7 Q8NCY8

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003079 (ROR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T More...
CREDO 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T More...
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