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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741165
Target Type SINGLE PROTEIN
Preferred Name Microphthalmia-associated transcription factor
Synonyms BHLHE32 | Class E basic helix-loop-helix protein 32 | MITF | Microphthalmia-associated transcription factor | bHLHe32
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Microphthalmia-associated transcription factor SINGLE PROTEIN O75030

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187098
Ensembl ENSG00000187098
GO Cellular Component GO:0005634 (nucleus)
GO Molecular Function GO:0003677 (DNA binding)
GO:0016563 (transcription activator activity)
GO Biological Process GO:0006351 (transcription, DNA-dependent)
GO:0006355 (regulation of transcription, DNA-dependent)
GO:0007275 (multicellular organismal development)
GO:0030318 (melanocyte differentiation)
Wikipedia Microphthalmia-associated_transcription_factor

Target Cross References - Protein

canSAR O75030
CGD Waardenburg syndrome, type 2A; Tietz albinism-deafness syndrome
Human Protein Atlas ENSG00000187098
PharmGKB PA30823
UniProt O75030 Q14841 Q9P2V0 Q9P2V1 Q9P2V2 Q9P2Y8

Target Cross References - Domain

InterPro IPR001092 (HLH_DNA-bd_dom.)
IPR011598 (HLH_DNA-bd.)
IPR021802 (DUF3371.)
Pfam PF00010 (HLH)
PF11851 (DUF3371)
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