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Target Report Card

Target Name and Classification

Target ID CHEMBL1741165
Preferred Name Microphthalmia-associated transcription factor
Synonyms BHLHE32 | Class E basic helix-loop-helix protein 32 | MITF | Microphthalmia-associated transcription factor | bHLHe32
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Microphthalmia-associated transcription factor SINGLE PROTEIN O75030

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187098
Ensembl ENSG00000187098
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0043234 (protein complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006461 (protein complex assembly)
GO:0007275 (multicellular organism development)
GO:0010628 (positive regulation of gene expression)
GO:0016925 (protein sumoylation)
GO:0030318 (melanocyte differentiation)
GO:0042981 (regulation of apoptotic process)
GO:0043473 (pigmentation)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0097531 (mast cell migration)
GO:2000144 (positive regulation of DNA-templated transcription, initiation)
GO:2001141 (regulation of RNA biosynthetic process)
Wikipedia Microphthalmia-associated_transcription_factor

Target Cross References - Protein

canSAR O75030
CGD Waardenburg syndrome, type 2A; Tietz albinism-deafness syndrome
Human Protein Atlas ENSG00000187098
IntAct O75030
Open Targets ENSG00000187098
PharmGKB PA30823
Reactome R-HSA-3232118 (SUMOylation of transcription factors.)
UniProt B4DJL2 D3K197 E9PFN0 O75030 Q14841 Q9P2V0 Q9P2V1 Q9P2V2 Q9P2Y8

Target Cross References - Domain

InterPro IPR011598 (bHLH_dom.)
IPR021802 (MiT/TFE_C.)
IPR030532 (MITF.)
IPR031867 (MiT/TFE_N.)
Pfam PF00010 (HLH)
PF11851 (DUF3371)
PF15951 (MITF_TFEB_C_3_N)

Target Cross References - Structure