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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1741162
Target Type SINGLE PROTEIN
Preferred Name Phosphomannomutase 2
Synonyms PMM 2 | PMM2 | Phosphomannomutase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphomannomutase 2 SINGLE PROTEIN O15305

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140650
Ensembl ENSG00000140650
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043025 (neuronal cell body)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004615 (phosphomannomutase activity)
GO:0005515 (protein binding)
GO:0016853 (isomerase activity)
GO Biological Process GO:0006486 (protein glycosylation)
GO:0009298 (GDP-mannose biosynthetic process)
Wikipedia PMM2

Target Cross References - Protein

CGD Congenital disorder of glycosylation, type Ia
Human Protein Atlas ENSG00000140650
IntAct O15305
Open Targets ENSG00000140650
PharmGKB PA33441
Reactome R-HSA-446205 (Synthesis of GDP-mannose.)
UniProt A8K672 B7Z6R0 D3DUF3 O15305

Target Cross References - Domain

InterPro IPR005002 (PMM.)
IPR006379 (HAD-SF_hydro_IIB.)
IPR023214 (HAD-like_dom.)
Pfam PF03332 (PMM)

Target Cross References - Structure

PDBe 2AMY 2Q4R
CREDO 2AMY 2Q4R
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