ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1697671
Target Type SINGLE PROTEIN
Preferred Name Placenta growth factor
Synonyms PGF | PGFL | PLGF | PlGF | Placenta growth factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Placenta growth factor SINGLE PROTEIN P49763

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1742982 AFLIBERCEPT Placenta growth factor inhibitor 4 DailyMed DailyMed
CHEMBL2108313 CONBERCEPT Placenta growth factor inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119630
Ensembl ENSG00000119630
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0016020 (membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008201 (heparin binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001666 (response to hypoxia)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002040 (sprouting angiogenesis)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0007565 (female pregnancy)
GO:0008284 (positive regulation of cell proliferation)
GO:0030154 (cell differentiation)
GO:0031100 (organ regeneration)
GO:0032870 (cellular response to hormone stimulus)
GO:0042493 (response to drug)
GO:0045766 (positive regulation of angiogenesis)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0051781 (positive regulation of cell division)
GO:0060688 (regulation of morphogenesis of a branching structure)
Wikipedia Placental_growth_factor

Target Cross References - Protein

Human Protein Atlas ENSG00000119630
IntAct P49763
Open Targets ENSG00000119630
PharmGKB PA33231
Reactome R-HSA-194313 (VEGF ligand-receptor interactions.)
R-HSA-195399 (VEGF binds to VEGFR leading to receptor dimerization.)
UniProt P49763 Q07101 Q9BV78 Q9Y6S8

Target Cross References - Domain

InterPro IPR000072 (PDGF/VEGF_dom.)
IPR023581 (PD_growth_factor_CS.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00341 (PDGF)

Target Cross References - Structure

PDBe 1FZV 1RV6
CREDO 1FZV 1RV6
spacer
spacer