ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1697669
Target Type SINGLE PROTEIN
Preferred Name Cadherin-2
Synonyms CDH2 | CDHN | CD_antigen=CD325 | CDw325 | Cadherin-2 | N-cadherin | NCAD | Neural cadherin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cadherin-2 SINGLE PROTEIN P19022

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170558
Ensembl ENSG00000170558
GO Cellular Component GO:0030027 (lamellipodium)
GO:0044853 (plasma membrane raft)
GO:0016324 (apical plasma membrane)
GO:0016342 (catenin complex)
GO:0005913 (cell-cell adherens junction)
GO:0005925 (focal adhesion)
GO:0070062 (extracellular exosome)
GO:0005916 (fascia adherens)
GO:0045202 (synapse)
GO:0005737 (cytoplasm)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0014704 (intercalated disc)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0045295 (gamma-catenin binding)
GO:0045294 (alpha-catenin binding)
GO:0008013 (beta-catenin binding)
GO Biological Process GO:0034329 (cell junction assembly)
GO:0035023 (regulation of Rho protein signal transduction)
GO:0042692 (muscle cell differentiation)
GO:0051146 (striated muscle cell differentiation)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0045216 (cell-cell junction organization)
GO:0048514 (blood vessel morphogenesis)
GO:0070445 (regulation of oligodendrocyte progenitor proliferation)
GO:0090002 (establishment of protein localization to plasma membrane)
GO:2000809 (positive regulation of synaptic vesicle clustering)
GO:0031641 (regulation of myelination)
GO:0050770 (regulation of axonogenesis)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0060019 (radial glial cell differentiation)
GO:0021987 (cerebral cortex development)
GO:0097150 (neuronal stem cell population maintenance)
GO:0043410 (positive regulation of MAPK cascade)
GO:0048872 (homeostasis of number of cells)
GO:0051291 (protein heterooligomerization)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0007155 (cell adhesion)
GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
GO:0010001 (glial cell differentiation)
GO:0016339 (calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0060563 (neuroepithelial cell differentiation)
GO:0097118 (neuroligin clustering involved in postsynaptic membrane assembly)
GO:1902897 (regulation of postsynaptic density protein 95 clustering)
GO:0016477 (cell migration)
GO:0034332 (adherens junction organization)
GO:0044331 (cell-cell adhesion mediated by cadherin)
GO:0048854 (brain morphogenesis)
Wikipedia CDH2

Target Cross References - Protein

Human Protein Atlas ENSG00000170558
IntAct P19022
PharmGKB PA26293
UniProt P19022 Q14923 Q8N173 B0YIY6

Target Cross References - Domain

InterPro IPR000233 (Cadherin_cytoplasmic-dom.)
IPR002126 (Cadherin.)
IPR027397 (Catenin_binding_dom.)
IPR014868 (Cadherin_pro_dom.)
IPR030051 (CDH2.)
IPR015919 (Cadherin-like.)
IPR020894 (Cadherin_CS.)
Pfam PF00028 (Cadherin)
PF01049 (Cadherin_C)
PF08758 (Cadherin_pro)
spacer
spacer