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Target Report Card

Target Name and Classification

Target ID CHEMBL1697669
Preferred Name Cadherin-2
Synonyms CDH2 | CDHN | CD_antigen=CD325 | CDw325 | Cadherin-2 | N-cadherin | NCAD | Neural cadherin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cadherin-2 SINGLE PROTEIN P19022

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170558
Ensembl ENSG00000170558
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005912 (adherens junction)
GO:0005913 (cell-cell adherens junction)
GO:0005916 (fascia adherens)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0016342 (catenin complex)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030864 (cortical actin cytoskeleton)
GO:0031012 (extracellular matrix)
GO:0042383 (sarcolemma)
GO:0044853 (plasma membrane raft)
GO:0045202 (synapse)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0042802 (identical protein binding)
GO:0045294 (alpha-catenin binding)
GO:0045295 (gamma-catenin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007155 (cell adhesion)
GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0009966 (regulation of signal transduction)
GO:0010001 (glial cell differentiation)
GO:0016339 (calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0016477 (cell migration)
GO:0021537 (telencephalon development)
GO:0021987 (cerebral cortex development)
GO:0034332 (adherens junction organization)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0044331 (cell-cell adhesion mediated by cadherin)
GO:0048514 (blood vessel morphogenesis)
GO:0048854 (brain morphogenesis)
GO:0048872 (homeostasis of number of cells)
GO:0051146 (striated muscle cell differentiation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0060019 (radial glial cell differentiation)
GO:0060563 (neuroepithelial cell differentiation)
GO:0070445 (regulation of oligodendrocyte progenitor proliferation)
GO:0072659 (protein localization to plasma membrane)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097118 (neuroligin clustering involved in postsynaptic membrane assembly)
GO:0097150 (neuronal stem cell population maintenance)
GO:1902897 (regulation of postsynaptic density protein 95 clustering)
GO:2000809 (positive regulation of synaptic vesicle clustering)
Wikipedia CDH2

Target Cross References - Protein

Human Protein Atlas ENSG00000170558
IntAct P19022
Open Targets ENSG00000170558
PharmGKB PA26293
Reactome R-HSA-375170 (CDO in myogenesis.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-418990 (Adherens junctions interactions.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
UniProt A8MWK3 B0YIY6 P19022 Q14923 Q8N173

Target Cross References - Domain

InterPro IPR000233 (Cadherin_cytoplasmic-dom.)
IPR002126 (Cadherin.)
IPR014868 (Cadherin_pro_dom.)
IPR015919 (Cadherin-like.)
IPR020894 (Cadherin_CS.)
IPR027397 (Catenin_binding_dom_sf.)
IPR030051 (CDH2.)
Pfam PF00028 (Cadherin)
PF01049 (Cadherin_C)
PF08758 (Cadherin_pro)