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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1697668
Target Type SINGLE PROTEIN
Preferred Name Solute carrier organic anion transporter family member 1B1
Synonyms LST-1 | LST1 | Liver-specific organic anion transporter 1 | OATP-2 | OATP-C | OATP1B1 | OATP2 | OATPC | SLC21A6 | SLCO1B1 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 6 | Solute carrier organic anion transporter family member 1B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc21/slco family of organic anion transporting polypeptides

Target Components

Component Description Relationship Accession
Solute carrier organic anion transporter family member 1B1 SINGLE PROTEIN Q9Y6L6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134538
Ensembl ENSG00000134538
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0015125 (bile acid transmembrane transporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO:0015349 (thyroid hormone transmembrane transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0008206 (bile acid metabolic process)
GO:0015711 (organic anion transport)
GO:0015721 (bile acid and bile salt transport)
GO:0043252 (sodium-independent organic anion transport)
GO:0070327 (thyroid hormone transport)
Wikipedia SLCO1B1

Target Cross References - Protein

CGD Statin-induced myopathy; Hyperbilirubinemia, Rotor type, digenic
Human Protein Atlas ENSG00000134538
Guide to Pharmacology 1220
Open Targets ENSG00000134538
PharmGKB PA134865839
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-5619110 (Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR).)
R-HSA-5661182 (Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR).)
R-HSA-879518 (Transport of organic anions.)
UniProt B2R7G2 Q29R64 Q9NQ37 Q9UBF3 Q9UH89 Q9Y6L6

Target Cross References - Domain

InterPro IPR002350 (Kazal_dom.)
IPR004156 (OA_transporter.)
IPR020846 (MFS_dom.)
Pfam PF03137 (OATP)
PF07648 (Kazal_2)
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