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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1687681
Target Type SINGLE PROTEIN
Preferred Name T-box transcription factor TBX5
Synonyms T-box protein 5 | T-box transcription factor TBX5 | TBX5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
T-box transcription factor TBX5 SINGLE PROTEIN Q99593

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089225
Ensembl ENSG00000089225
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003702 (RNA polymerase II transcription factor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0003218 (cardiac left ventricle formation)
GO:0003281 (ventricular septum development)
GO:0006917 (induction of apoptosis)
GO:0007267 (cell-cell signaling)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0030336 (negative regulation of cell migration)
GO:0035117 (embryonic arm morphogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051891 (positive regulation of cardioblast differentiation)
GO:0060039 (pericardium development)
GO:0060044 (negative regulation of cardiac muscle cell proliferation)
GO:0060980 (cell migration involved in coronary vasculogenesis)
Wikipedia TBX5_(gene)

Target Cross References - Protein

CGD Holt-Oram syndrome
Human Protein Atlas ENSG00000089225
IntAct Q99593
PharmGKB PA36367
UniProt O15301 Q99593 Q9Y4I2

Target Cross References - Domain

InterPro IPR001699 (TF_T-box.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR018186 (TF_T-box_CS.)
Pfam PF00907 (T-box)

Target Cross References - Structure

PDBe 2X6U 2X6V
CREDO 2X6U 2X6V
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