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Target Report Card

Target Name and Classification

Target ID CHEMBL1687681
Preferred Name T-box transcription factor TBX5
Synonyms T-box protein 5 | T-box transcription factor TBX5 | TBX5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
T-box transcription factor TBX5 SINGLE PROTEIN Q99593

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089225
Ensembl ENSG00000089225
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0002009 (morphogenesis of an epithelium)
GO:0003166 (bundle of His development)
GO:0003181 (atrioventricular valve morphogenesis)
GO:0003197 (endocardial cushion development)
GO:0003218 (cardiac left ventricle formation)
GO:0003229 (ventricular cardiac muscle tissue development)
GO:0003281 (ventricular septum development)
GO:0003283 (atrial septum development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0007389 (pattern specification process)
GO:0007507 (heart development)
GO:0008285 (negative regulation of cell proliferation)
GO:0010719 (negative regulation of epithelial to mesenchymal transition)
GO:0030324 (lung development)
GO:0030326 (embryonic limb morphogenesis)
GO:0030336 (negative regulation of cell migration)
GO:0035115 (embryonic forelimb morphogenesis)
GO:0035136 (forelimb morphogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051891 (positive regulation of cardioblast differentiation)
GO:0055007 (cardiac muscle cell differentiation)
GO:0060039 (pericardium development)
GO:0060044 (negative regulation of cardiac muscle cell proliferation)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060290 (transdifferentiation)
GO:0060413 (atrial septum morphogenesis)
GO:0060980 (cell migration involved in coronary vasculogenesis)
GO:0072513 (positive regulation of secondary heart field cardioblast proliferation)
GO:1900117 (regulation of execution phase of apoptosis)
Wikipedia TBX5_(gene)

Target Cross References - Protein

CGD Holt-Oram syndrome
Human Protein Atlas ENSG00000089225
IntAct Q99593
Open Targets ENSG00000089225
PharmGKB PA36367
Reactome R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-5578768 (Physiological factors.)
UniProt A6ND77 O15301 Q96TB0 Q99593 Q9Y4I2

Target Cross References - Domain

InterPro IPR001699 (TF_T-box.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR018186 (TF_T-box_CS.)
Pfam PF00907 (T-box)

Target Cross References - Structure

PDBe 2X6U 2X6V 4S0H 5BQD