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Target Report Card

Target Name and Classification

Target ID CHEMBL1687679
Preferred Name Transcription factor GATA-4
Synonyms GATA-binding factor 4 | GATA4 | Transcription factor GATA-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor GATA-4 SINGLE PROTEIN P43694

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136574
Ensembl ENSG00000136574
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0016604 (nuclear body)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001076 (transcription factor activity, RNA polymerase II transcription factor binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001158 (enhancer sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0019901 (protein kinase binding)
GO:0033613 (activating transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0051525 (NFAT protein binding)
GO:0070410 (co-SMAD binding)
GO Biological Process GO:0001947 (heart looping)
GO:0003197 (endocardial cushion development)
GO:0003208 (cardiac ventricle morphogenesis)
GO:0003215 (cardiac right ventricle morphogenesis)
GO:0003281 (ventricular septum development)
GO:0003289 (atrial septum primum morphogenesis)
GO:0003290 (atrial septum secundum morphogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007267 (cell-cell signaling)
GO:0007492 (endoderm development)
GO:0007596 (blood coagulation)
GO:0008584 (male gonad development)
GO:0009612 (response to mechanical stimulus)
GO:0010507 (negative regulation of autophagy)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0030513 (positive regulation of BMP signaling pathway)
GO:0033189 (response to vitamin A)
GO:0035054 (embryonic heart tube anterior/posterior pattern specification)
GO:0042493 (response to drug)
GO:0045766 (positive regulation of angiogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048617 (embryonic foregut morphogenesis)
GO:0051891 (positive regulation of cardioblast differentiation)
GO:0055007 (cardiac muscle cell differentiation)
GO:0060290 (transdifferentiation)
GO:0060413 (atrial septum morphogenesis)
GO:0060575 (intestinal epithelial cell differentiation)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071333 (cellular response to glucose stimulus)
GO:0086004 (regulation of cardiac muscle cell contraction)
Wikipedia GATA4

Target Cross References - Protein

CGD Atrioventricular septal defect 4; Ventricular septal defect 1; Atrial septal defect 2; Tetralogy of Fallot
Human Protein Atlas ENSG00000136574
IntAct P43694
Open Targets ENSG00000136574
PharmGKB PA28587
Reactome R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-400511 (Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).)
R-HSA-5578768 (Physiological factors.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B7ZKX0 B7ZKZ4 P43694 Q3MJ45 Q5IFM8

Target Cross References - Domain

InterPro IPR000679 (Znf_GATA.)
IPR008013 (GATA_N.)
IPR013088 (Znf_NHR/GATA.)
IPR016375 (TF_GATA_4/5/6.)
Pfam PF00320 (GATA)
PF05349 (GATA-N)