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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1681618
Target Type SINGLE PROTEIN
Preferred Name Coproporphyrinogen-III oxidase, mitochondrial
Synonyms COX | CPO | CPOX | CPX | Coprogen oxidase | Coproporphyrinogenase | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial SINGLE PROTEIN P36551

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080819
Ensembl ENSG00000080819
GO Cellular Component GO:0005758 (mitochondrial intermembrane space)
GO Molecular Function GO:0004109 (coproporphyrinogen oxidase activity)
GO:0042803 (protein homodimerization activity)
Wikipedia Coproporphyrinogen_III_oxidase

Target Cross References - Protein

CGD Coproporphyria, hereditary; Harderoporphyria
Human Protein Atlas ENSG00000080819
PharmGKB PA134979958
Reactome REACT_9431 (Metabolism of porphyrins.)
UniProt A8K275 P36551 Q14060 Q53F08 Q8IZ45 Q96AF3

Target Cross References - Domain

InterPro IPR001260 (Coprogen_oxidase_aer.)
IPR018375 (Coprogen_oxidase_CS.)
Pfam PF01218 (Coprogen_oxidas)

Target Cross References - Structure

PDBe 2AEX
CREDO 2AEX
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