ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1681618
Target Type SINGLE PROTEIN
Preferred Name Coproporphyrinogen-III oxidase, mitochondrial
Synonyms COX | CPO | CPOX | CPX | Coprogen oxidase | Coproporphyrinogenase | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial SINGLE PROTEIN P36551

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080819
Ensembl ENSG00000080819
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0016020 (membrane)
GO Molecular Function GO:0004109 (coproporphyrinogen oxidase activity)
GO:0005212 (structural constituent of eye lens)
GO:0016491 (oxidoreductase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006779 (porphyrin-containing compound biosynthetic process)
GO:0006782 (protoporphyrinogen IX biosynthetic process)
GO:0006783 (heme biosynthetic process)
GO:0010035 (response to inorganic substance)
GO:0010039 (response to iron ion)
GO:0010288 (response to lead ion)
GO:0017085 (response to insecticide)
GO:0046685 (response to arsenic-containing substance)
GO:0051597 (response to methylmercury)
GO:0055114 (oxidation-reduction process)
Wikipedia Coproporphyrinogen_III_oxidase

Target Cross References - Protein

CGD Coproporphyria, hereditary; Harderoporphyria
Human Protein Atlas ENSG00000080819
IntAct P36551
Open Targets ENSG00000080819
PharmGKB PA134979958
Reactome R-HSA-189451 (Heme biosynthesis.)
UniProt A8K275 B4DSD5 P36551 Q14060 Q53F08 Q8IZ45 Q96AF3

Target Cross References - Domain

InterPro IPR001260 (Coprogen_oxidase_aer.)
IPR018375 (Coprogen_oxidase_CS.)
Pfam PF01218 (Coprogen_oxidas)

Target Cross References - Structure

PDBe 2AEX
CREDO 2AEX
spacer
spacer