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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1671609
Target Type SINGLE PROTEIN
Preferred Name ERO1-like protein alpha
Synonyms ERO1-L | ERO1-L-alpha | ERO1-like protein alpha | ERO1A | ERO1L | Endoplasmic oxidoreductin-1-like protein | Endoplasmic reticulum oxidoreductase alpha | Oxidoreductin-1-L-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ERO1-like protein alpha SINGLE PROTEIN Q96HE7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197930
Ensembl ENSG00000197930
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003756 (protein disulfide isomerase activity)
GO:0015035 (protein disulfide oxidoreductase activity)
GO:0015036 (disulfide oxidoreductase activity)
GO:0016491 (oxidoreductase activity)
GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0006457 (protein folding)
GO:0006464 (cellular protein modification process)
GO:0006467 (protein thiol-disulfide exchange)
GO:0006810 (transport)
GO:0009266 (response to temperature stimulus)
GO:0019471 (4-hydroxyproline metabolic process)
GO:0022417 (protein maturation by protein folding)
GO:0022900 (electron transport chain)
GO:0030198 (extracellular matrix organization)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0044267 (cellular protein metabolic process)
GO:0045454 (cell redox homeostasis)
GO:0050873 (brown fat cell differentiation)
GO:0051085 (chaperone mediated protein folding requiring cofactor)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
Wikipedia ERO1L

Target Cross References - Protein

Human Protein Atlas ENSG00000197930
IntAct Q96HE7
PharmGKB PA27862
UniProt A8K9X4 A8MYW1 Q7LD45 Q96HE7 Q9P1Q9 Q9UKV6

Target Cross References - Domain

InterPro IPR007266 (ER_oxidoreductin-1.)
IPR007266 (Ero1.)
Pfam PF04137 (ERO1)

Target Cross References - Structure

PDBe 3AHQ 3AHR
CREDO 3AHQ 3AHR
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