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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1649058
Target Type SINGLE PROTEIN
Preferred Name Beta-nerve growth factor
Synonyms Beta-NGF | Beta-nerve growth factor | NGF | NGFB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Beta-nerve growth factor SINGLE PROTEIN P01138

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743023 FULRANUMAB Beta-nerve growth factor inhibitor 3 PubMed
CHEMBL2108567 TANEZUMAB Beta-nerve growth factor inhibitor 3 PubMed
CHEMBL2109528 Fasinumab Beta-nerve growth factor inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134259
Ensembl ENSG00000134259
GO Cellular Component GO:0005576 (extracellular region)
GO:0005768 (endosome)
GO:0005796 (Golgi lumen)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO Molecular Function GO:0004857 (enzyme inhibitor activity)
GO:0005102 (receptor binding)
GO:0005163 (nerve growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008191 (metalloendopeptidase inhibitor activity)
GO:0030414 (peptidase inhibitor activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007018 (microtubule-based movement)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0010466 (negative regulation of peptidase activity)
GO:0010628 (positive regulation of gene expression)
GO:0032455 (nerve growth factor processing)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045664 (regulation of neuron differentiation)
GO:0046579 (positive regulation of Ras protein signal transduction)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048812 (neuron projection morphogenesis)
GO:0050772 (positive regulation of axonogenesis)
Wikipedia Nerve_growth_factor

Target Cross References - Protein

CGD Neuropathy, hereditary sensory and autonomic, type V
Human Protein Atlas ENSG00000134259
IntAct P01138
Open Targets ENSG00000134259
PharmGKB PA162397475
Reactome R-HSA-167021 (PLC-gamma1 signalling.)
R-HSA-167044 (Signalling to RAS.)
R-HSA-167060 (NGF processing.)
R-HSA-170968 (Frs2-mediated activation.)
R-HSA-170984 (ARMS-mediated activation.)
R-HSA-177504 (Retrograde neurotrophin signalling.)
R-HSA-187042 (TRKA activation by NGF.)
R-HSA-187706 (Signalling to p38 via RIT and RIN.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-193681 (Ceramide signalling.)
R-HSA-198203 (PI3K/AKT activation.)
R-HSA-198745 (Signalling to STAT3.)
R-HSA-205017 (NFG and proNGF binds to p75NTR.)
R-HSA-205025 (NADE modulates death signalling.)
R-HSA-205043 (NRIF signals cell death from the nucleus.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-209563 (Axonal growth stimulation.)
UniProt A1A4E5 P01138 Q6FHA0 Q96P60 Q9P2Q8 Q9UKL8

Target Cross References - Domain

InterPro IPR002072 (Nerve_growth_factor-rel.)
IPR019846 (Nerve_growth_factor_CS.)
IPR020408 (Nerve_growth_factor-like.)
IPR020425 (Nerve_growth_factor_bsu.)
IPR020437 (Nerve_growth_factor_bsu_mml.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00243 (NGF)

Target Cross References - Structure

PDBe 1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7
CREDO 1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7
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