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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL1649050
Target Type SINGLE PROTEIN
Preferred Name Cholecystokinin
Synonyms (1-49)-CCK58 | CCK | CCK | CCK12 | CCK18 | CCK25 | CCK33 | CCK39 | CCK5 | CCK58 | CCK7 | CCK8 | Cholecystokinin | Cholecystokinin-12 | Cholecystokinin-18 | Cholecystokinin-25 | Cholecystokinin-33 | Cholecystokinin-39 | Cholecystokinin-5 | Cholecystokinin-58 desnonopeptide | Cholecystokinin-58 | Cholecystokinin-7 | Cholecystokinin-8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cholecystokinin SINGLE PROTEIN P06307

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187094
Ensembl ENSG00000187094
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043194 (axon initial segment)
GO:0043195 (terminal bouton)
GO:0043203 (axon hillock)
GO:0043204 (perikaryon)
GO Molecular Function GO:0005179 (hormone activity)
GO:0005184 (neuropeptide hormone activity)
GO:0005515 (protein binding)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0001764 (neuron migration)
GO:0001836 (release of cytochrome c from mitochondria)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007165 (signal transduction)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007409 (axonogenesis)
GO:0008284 (positive regulation of cell proliferation)
GO:0014049 (positive regulation of glutamate secretion)
GO:0032099 (negative regulation of appetite)
GO:0032461 (positive regulation of protein oligomerization)
GO:0042755 (eating behavior)
GO:0043065 (positive regulation of apoptotic process)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051901 (positive regulation of mitochondrial depolarization)
GO:0051930 (regulation of sensory perception of pain)
Wikipedia Cholecystokinin

Target Cross References - Protein

Human Protein Atlas ENSG00000187094
IntAct P06307
Open Targets ENSG00000187094
PharmGKB PA26141
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P06307

Target Cross References - Domain

InterPro IPR001651 (Gastrin.)
IPR013152 (Gastrin/cholecystokinin_CS.)
IPR015499 (CCK-like.)
Pfam PF00918 (Gastrin)
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