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Target Report Card

Target Name and Classification

Target ID CHEMBL1641353
Target Type SINGLE PROTEIN
Preferred Name DNA-directed RNA polymerase II subunit RPB1
Synonyms DNA-directed RNA polymerase II subunit A | DNA-directed RNA polymerase II subunit RPB1 | DNA-directed RNA polymerase III largest subunit | POLR2 | POLR2A | RNA polymerase II subunit B1 | RNA-directed RNA polymerase II subunit RPB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA-directed RNA polymerase II subunit RPB1 SINGLE PROTEIN P24928

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181222
Ensembl ENSG00000181222
GO Cellular Component GO:0000974 (Prp19 complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005665 (DNA-directed RNA polymerase II, core complex)
GO:0005730 (nucleolus)
GO Molecular Function GO:0001055 (RNA polymerase II activity)
GO:0003677 (DNA binding)
GO:0003899 (DNA-directed RNA polymerase activity)
GO:0003968 (RNA-directed RNA polymerase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000398 (mRNA splicing, via spliceosome)
GO:0001172 (transcription, RNA-templated)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006351 (transcription, DNA-templated)
GO:0006353 (DNA-templated transcription, termination)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006370 (7-methylguanosine mRNA capping)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0010467 (gene expression)
GO:0031047 (gene silencing by RNA)
GO:0033120 (positive regulation of RNA splicing)
GO:0035019 (somatic stem cell population maintenance)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
GO:0050434 (positive regulation of viral transcription)
Wikipedia POLR2A

Target Cross References - Protein

Human Protein Atlas ENSG00000181222
IntAct P24928
Open Targets ENSG00000181222
PharmGKB PA33507
Reactome R-HSA-112382 (Formation of RNA Pol II elongation complex.)
R-HSA-112387 (Elongation arrest and recovery.)
R-HSA-113418 (Formation of the Early Elongation Complex.)
R-HSA-167152 (Formation of HIV elongation complex in the absence of HIV Tat.)
R-HSA-167158 (Formation of the HIV-1 Early Elongation Complex.)
R-HSA-167160 (RNA Pol II CTD phosphorylation and interaction with CE during HIV infection.)
R-HSA-167161 (HIV Transcription Initiation.)
R-HSA-167162 (RNA Polymerase II HIV Promoter Escape.)
R-HSA-167172 (Transcription of the HIV genome.)
R-HSA-167200 (Formation of HIV-1 elongation complex containing HIV-1 Tat.)
R-HSA-167238 (Pausing and recovery of Tat-mediated HIV elongation.)
R-HSA-167242 (Abortive elongation of HIV-1 transcript in the absence of Tat.)
R-HSA-167243 (Tat-mediated HIV elongation arrest and recovery.)
R-HSA-167246 (Tat-mediated elongation of the HIV-1 transcript.)
R-HSA-167287 (HIV elongation arrest and recovery.)
R-HSA-167290 (Pausing and recovery of HIV elongation.)
R-HSA-168325 (Viral Messenger RNA Synthesis.)
R-HSA-203927 (MicroRNA (miRNA) biogenesis.)
R-HSA-452723 (Transcriptional regulation of pluripotent stem cells.)
R-HSA-5578749 (Transcriptional regulation by small RNAs.)
R-HSA-5601884 (PIWI-interacting RNA (piRNA) biogenesis.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-674695 (RNA Polymerase II Pre-transcription Events.)
R-HSA-6781823 (Formation of TC-NER Pre-Incision Complex.)
R-HSA-6781827 (Transcription-Coupled Nucleotide Excision Repair (TC-NER).)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6803529 (FGFR2 alternative splicing.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
R-HSA-72086 (mRNA Capping.)
R-HSA-72163 (mRNA Splicing - Major Pathway.)
R-HSA-72165 (mRNA Splicing - Minor Pathway.)
R-HSA-72203 (Processing of Capped Intron-Containing Pre-mRNA.)
R-HSA-73776 (RNA Polymerase II Promoter Escape.)
R-HSA-73779 (RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.)
R-HSA-75953 (RNA Polymerase II Transcription Initiation.)
R-HSA-75955 (RNA Polymerase II Transcription Elongation.)
R-HSA-76042 (RNA Polymerase II Transcription Initiation And Promoter Clearance.)
R-HSA-77075 (RNA Pol II CTD phosphorylation and interaction with CE.)
R-HSA-8851708 (Signaling by FGFR2 IIIa TM.)
UniProt A6NN93 B9EH88 P24928 Q6NX41

Target Cross References - Domain

InterPro IPR000684 (RNA_pol_II_repeat_euk.)
IPR000722 (RNA_pol_asu.)
IPR006592 (RNA_pol_N.)
IPR007066 (RNA_pol_Rpb1_3.)
IPR007073 (RNA_pol_Rpb1_7.)
IPR007075 (RNA_pol_Rpb1_6.)
IPR007080 (RNA_pol_Rpb1_1.)
IPR007081 (RNA_pol_Rpb1_5.)
IPR007083 (RNA_pol_Rpb1_4.)
Pfam PF00623 (RNA_pol_Rpb1_2)
PF04983 (RNA_pol_Rpb1_3)
PF04990 (RNA_pol_Rpb1_7)
PF04992 (RNA_pol_Rpb1_6)
PF04997 (RNA_pol_Rpb1_1)
PF04998 (RNA_pol_Rpb1_5)
PF05000 (RNA_pol_Rpb1_4)
PF05001 (RNA_pol_Rpb1_R)

Target Cross References - Structure

PDBe 2GHQ 2GHT 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT
CREDO 2GHQ 2GHT 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT
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