ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1641348
Target Type SINGLE PROTEIN
Preferred Name Solute carrier family 22 member 8
Synonyms OAT3 | Organic anion transporter 3 | SLC22A8 | Solute carrier family 22 member 8 | hOAT3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc22 family of organic cation and anion transporters

Target Components

Component Description Relationship Accession
Solute carrier family 22 member 8 SINGLE PROTEIN Q8TCC7

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL897 PROBENECID Solute carrier family 22 member 8 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL41194 PRATOSARTAN Solute carrier family 22 member 8 inhibitor 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149452
Ensembl ENSG00000149452
GO Cellular Component GO:0005624 (membrane fraction)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005887 (integral to plasma membrane)
GO:0016323 (basolateral plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005452 (inorganic anion exchanger activity)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO Biological Process GO:0009636 (response to toxic substance)
GO:0009636 (response to toxin)
GO:0043252 (sodium-independent organic anion transport)
GO:0055085 (transmembrane transport)
GO:0098656 (anion transmembrane transport)
Wikipedia SLC22A8

Target Cross References - Protein

Human Protein Atlas ENSG00000149452
IntAct Q8TCC7
PharmGKB PA389
UniProt O95820 Q59EW9 Q8TCC7 Q96TC1

Target Cross References - Domain

InterPro IPR004749 (Orgcat_transp.)
IPR004749 (Orgcat_transp/SVOP.)
IPR005828 (MFS_sugar_transport_like.)
IPR005828 (Sub_transporter.)
IPR005829 (Sugar_transporter_CS.)
IPR016196 (MFS_dom_general_subst_transpt.)
IPR020846 (MFS_dom.)
Pfam PF00083 (Sugar_tr)
spacer
spacer