ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1641347
Target Type SINGLE PROTEIN
Preferred Name Solute carrier family 22 member 6
Synonyms OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | SLC22A6 | Solute carrier family 22 member 6 | hOAT1 | hPAHT | hROAT1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc22 family of organic cation and anion transporters

Target Components

Component Description Relationship Accession
Solute carrier family 22 member 6 SINGLE PROTEIN Q4U2R8

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL897 PROBENECID Solute carrier family 22 member 6 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL41194 PRATOSARTAN Solute carrier family 22 member 6 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197901
Ensembl ENSG00000197901
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005452 (inorganic anion exchanger activity)
GO:0005515 (protein binding)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0015301 (anion:anion antiporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO:0022857 (transmembrane transporter activity)
GO:0031404 (chloride ion binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006820 (anion transport)
GO:0015698 (inorganic anion transport)
GO:0015711 (organic anion transport)
GO:0015742 (alpha-ketoglutarate transport)
GO:0031427 (response to methotrexate)
GO:0043252 (sodium-independent organic anion transport)
GO:0051260 (protein homooligomerization)
GO:0055085 (transmembrane transport)
GO:0097254 (renal tubular secretion)
GO:0098656 (anion transmembrane transport)
Wikipedia Organic_anion_transporter_1

Target Cross References - Protein

Human Protein Atlas ENSG00000197901
IntAct Q4U2R8
Guide to Pharmacology 1025
Open Targets ENSG00000197901
PharmGKB PA388
Reactome R-HSA-561048 (Organic anion transport.)
UniProt A8MY93 B2D0R6 O95187 O95742 Q4U2R8 Q7LDA0 Q8N192 Q9NQA6 Q9NQC2 Q9UBG6 Q9UEQ8

Target Cross References - Domain

InterPro IPR004749 (Orgcat_transp/SVOP.)
IPR005828 (MFS_sugar_transport-like.)
IPR020846 (MFS_dom.)
Pfam PF00083 (Sugar_tr)
spacer
spacer