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Target Report Card

Target Name and Classification

Target ID CHEMBL1628484
Preferred Name Amiloride-sensitive sodium channel subunit gamma
Synonyms Amiloride-sensitive sodium channel subunit gamma | ENaCG | Epithelial Na(+) channel subunit gamma | Gamma-ENaC | Gamma-NaCH | Nonvoltage-gated sodium channel 1 subunit gamma | SCNEG | SCNN1G
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > epithelial sodium channel

Target Components

Component Description Relationship Accession
Amiloride-sensitive sodium channel subunit gamma SINGLE PROTEIN P51170

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2107836 Amiloride-sensitive sodium channel, ENaC PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545352 P-1037 Amiloride-sensitive sodium channel subunit gamma blocker 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166828
Ensembl ENSG00000166828
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO:0034706 (sodium channel complex)
GO:0009897 (external side of plasma membrane)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0015280 (ligand-gated sodium channel activity)
GO:0005216 (ion channel activity)
GO:0005272 (sodium channel activity)
GO:0050699 (WW domain binding)
GO Biological Process GO:0050909 (sensory perception of taste)
GO:0055078 (sodium ion homeostasis)
GO:0055085 (transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0007588 (excretion)
GO:0006814 (sodium ion transport)
GO:0050891 (multicellular organismal water homeostasis)
GO:0034220 (ion transmembrane transport)
GO:0050896 (response to stimulus)
Wikipedia SCNN1G

Target Cross References - Protein

CGD Pseudohypoaldosteronism, type I; Liddle syndrome; Bronchiectasis with or without elevated sweat chloride 3
Human Protein Atlas ENSG00000166828
IntAct P51170
Guide to Pharmacology 741 (ENaC γ)
PharmGKB PA307
UniProt Q6PCC2 Q93023 Q93024 Q93025 Q93026 Q96TD2 P51170 P78437 Q93027

Target Cross References - Domain

InterPro IPR004724 (ENaC.)
IPR001873 (Na+channel_ASC.)
IPR020903 (Na+channel_ASC_CS.)
Pfam PF00858 (ASC)