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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1628480
Target Type SINGLE PROTEIN
Preferred Name Polycystic kidney disease 2-like 1 protein
Synonyms PKD2L | PKD2L1 | PKDL | Polycystic kidney disease 2-like 1 protein | Polycystin-2 homolog | Polycystin-2L1 | Polycystin-L | Polycystin-L1 | TRPP3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Polycystic kidney disease 2-like 1 protein SINGLE PROTEIN Q9P0L9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107593
Ensembl ENSG00000107593
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016021 (integral to membrane)
GO:0031513 (nonmotile primary cilium)
GO:0034704 (calcium channel complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO:0060170 (ciliary membrane)
GO Molecular Function GO:0005227 (calcium activated cation channel activity)
GO:0005261 (cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005272 (sodium channel activity)
GO:0005509 (calcium ion binding)
GO:0008092 (cytoskeletal protein binding)
GO:0015269 (calcium-activated potassium channel activity)
GO:0033040 (sour taste receptor activity)
GO:0042802 (identical protein binding)
GO:0051371 (muscle alpha-actinin binding)
GO:0051393 (alpha-actinin binding)
GO Biological Process GO:0001581 (detection of chemical stimulus involved in sensory perception of sour taste)
GO:0006812 (cation transport)
GO:0007165 (signal transduction)
GO:0007224 (smoothened signaling pathway)
GO:0035725 (sodium ion transmembrane transport)
GO:0050915 (sensory perception of sour taste)
GO:0050982 (detection of mechanical stimulus)
GO:0070207 (protein homotrimerization)
GO:0071468 (cellular response to acidic pH)
GO:0071805 (potassium ion transmembrane transport)
Wikipedia PKD2L1

Target Cross References - Protein

Human Protein Atlas ENSG00000107593
IntAct Q9P0L9
PharmGKB PA33344
UniProt O75972 Q5W039 Q9P0L9 Q9UP35 Q9UPA2

Target Cross References - Domain

InterPro IPR003915 (PKD_2.)
IPR011992 (EF-hand-dom_pair.)
IPR011992 (EF-hand-like_dom.)
IPR013122 (PKD1_2_channel.)
Pfam PF08016 (PKD_channel)

Target Cross References - Structure

PDBe 3TE3 4GIF
CREDO 3TE3 4GIF
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