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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1628478
Target Type SINGLE PROTEIN
Preferred Name Chloride channel protein 2
Synonyms CLCN2 | Chloride channel protein 2 | ClC-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > chloride channel > clc chloride channel

Target Components

Component Description Relationship Accession
Chloride channel protein 2 SINGLE PROTEIN P51788

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201134 LUBIPROSTONE Chloride channel protein 2 opener 4 DailyMed
CHEMBL2103799 COBIPROSTONE Chloride channel protein 2 activator 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114859
Ensembl ENSG00000114859
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034707 (chloride channel complex)
GO Molecular Function GO:0005244 (voltage-gated ion channel activity)
GO:0005247 (voltage-gated chloride channel activity)
GO:0005254 (chloride channel activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0034220 (ion transmembrane transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0060041 (retina development in camera-type eye)
GO:0060689 (cell differentiation involved in salivary gland development)
GO:1902476 (chloride transmembrane transport)
Wikipedia CLCN2

Target Cross References - Protein

CGD Epilepsy, idiopathic, generalized, susceptibility to, 11; Epilepsy, juvenile, absence, suscepibility to, 2; Epilepsy, juvenile myoclonic, susceptibility to, 8
Human Protein Atlas ENSG00000114859
IntAct P51788
Guide to Pharmacology 699
Open Targets ENSG00000114859
PharmGKB PA26547
Pharos P51788 (Tclin)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt B4DQT9 B4DZ58 E9PBD9 E9PCD2 O14864 P51788 Q6IPA9 Q8WU13

Target Cross References - Domain

InterPro IPR000644 (CBS_dom.)
IPR001807 (Cl-channel_volt-gated.)
IPR002244 (Cl-channel-2.)
IPR014743 (Cl-channel_core.)
Pfam PF00654 (Voltage_CLC)
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