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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1628476
Target Type SINGLE PROTEIN
Preferred Name cGMP-gated cation channel alpha-1
Synonyms CNCG | CNCG1 | CNG channel alpha-1 | CNG-1 | CNG1 | CNGA1 | Cyclic nucleotide-gated cation channel 1 | Cyclic nucleotide-gated channel alpha-1 | Cyclic nucleotide-gated channel, photoreceptor | Rod photoreceptor cGMP-gated channel subunit alpha | cGMP-gated cation channel alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > cyclic nucleotide-regulated channel

Target Components

Component Description Relationship Accession
cGMP-gated cation channel alpha-1 SINGLE PROTEIN P29973

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198515
Ensembl ENSG00000198515
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0030553 (cGMP binding)
GO Biological Process GO:0007601 (visual perception)
GO:0050896 (response to stimulus)
Wikipedia Cyclic_nucleotide-gated_channel_alpha_1

Target Cross References - Protein

CGD Retinitis pigmentosa 49
Human Protein Atlas ENSG00000198515
IUPHAR 394 (CNGA1)
PharmGKB PA26658
UniProt A8K7K6 P29973 Q16279 Q16485

Target Cross References - Domain

InterPro IPR000595 (cNMP-bd_dom.)
IPR005821 (Ion_trans.)
IPR014710 (RmlC-like_jellyroll.)
IPR018488 (cNMP-bd_CS.)
IPR018490 (cNMP-bd-like.)
Pfam PF00027 (cNMP_binding)
PF00520 (Ion_trans)
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