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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1628469
Target Type SINGLE PROTEIN
Preferred Name Transient receptor potential cation channel subfamily M member 4
Synonyms Calcium-activated non-selective cation channel 1 | LTRPC4 | LTrpC-4 | LTrpC4 | Long transient receptor potential channel 4 | Melastatin-4 | TRPM4 | Transient receptor potential cation channel subfamily M member 4 | hTRPM4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily M member 4 SINGLE PROTEIN Q8TD43

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130529
Ensembl ENSG00000130529
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0016021 (integral component of membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005227 (calcium activated cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002407 (dendritic cell chemotaxis)
GO:0002724 (regulation of T cell cytokine production)
GO:0008284 (positive regulation of cell proliferation)
GO:0016925 (protein sumoylation)
GO:0034220 (ion transmembrane transport)
GO:0042310 (vasoconstriction)
GO:0042391 (regulation of membrane potential)
GO:0055085 (transmembrane transport)
GO:0061337 (cardiac conduction)
GO:0070588 (calcium ion transmembrane transport)
GO:0090263 (positive regulation of canonical Wnt receptor signaling pathway)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
Wikipedia TRPM4

Target Cross References - Protein

CGD Progressive familial heart block, type IB
Human Protein Atlas ENSG00000130529
PharmGKB PA38272
UniProt A2RU25 Q7Z5D9 Q8TD43 Q96L84 Q9NXV1

Target Cross References - Domain

InterPro IPR005821 (Ion_trans.)
IPR005821 (Ion_trans_dom.)
IPR029581 (TRPM4.)
Pfam PF00520 (Ion_trans)
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