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Target Report Card

Target Name and Classification

Target ID CHEMBL1628469
Preferred Name Transient receptor potential cation channel subfamily M member 4
Synonyms Calcium-activated non-selective cation channel 1 | LTRPC4 | LTrpC-4 | LTrpC4 | Long transient receptor potential channel 4 | Melastatin-4 | TRPM4 | Transient receptor potential cation channel subfamily M member 4 | hTRPM4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily M member 4 SINGLE PROTEIN Q8TD43

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130529
Ensembl ENSG00000130529
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005216 (ion channel activity)
GO:0005227 (calcium activated cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005272 (sodium channel activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002407 (dendritic cell chemotaxis)
GO:0002724 (regulation of T cell cytokine production)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006816 (calcium ion transport)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008284 (positive regulation of cell proliferation)
GO:0010460 (positive regulation of heart rate)
GO:0016925 (protein sumoylation)
GO:0030502 (negative regulation of bone mineralization)
GO:0034220 (ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0042310 (vasoconstriction)
GO:0042391 (regulation of membrane potential)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0055085 (transmembrane transport)
GO:0061337 (cardiac conduction)
GO:0070588 (calcium ion transmembrane transport)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0098655 (cation transmembrane transport)
GO:1903949 (positive regulation of atrial cardiac muscle cell action potential)
GO:1904179 (positive regulation of adipose tissue development)
GO:1904199 (positive regulation of regulation of vascular smooth muscle cell membrane depolarization)
Wikipedia TRPM4

Target Cross References - Protein

CGD Progressive familial heart block, type IB
Human Protein Atlas ENSG00000130529
IntAct Q8TD43
Guide to Pharmacology 496
Open Targets ENSG00000130529
PharmGKB PA38272
Pharos Q8TD43 (Tchem)
Reactome R-HSA-3295583 (TRP channels.)
UniProt A2RU25 Q7Z5D9 Q8TD43 Q96L84 Q9NXV1

Target Cross References - Domain

InterPro IPR005821 (Ion_trans_dom.)
IPR029581 (TRPM4.)
Pfam PF00520 (Ion_trans)