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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1615388
Target Type SINGLE PROTEIN
Preferred Name SUMO-activating enzyme subunit 1
Synonyms AOS1 | SAE1 | SUA1 | SUMO-activating enzyme subunit 1 | SUMO-activating enzyme subunit 1, N-terminally processed | UBLE1A | Ubiquitin-like 1-activating enzyme E1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
SUMO-activating enzyme subunit 1 SINGLE PROTEIN Q9UBE0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137290 SUMO E1/E2 PROTEIN COMPLEX
CHEMBL2095174 SUMO-activating enzyme PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142230
Ensembl ENSG00000142230
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0031510 (SUMO activating enzyme complex)
GO Molecular Function GO:0004839 (ubiquitin activating enzyme activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008047 (enzyme activator activity)
GO:0008641 (small protein activating enzyme activity)
GO:0016874 (ligase activity)
GO:0019948 (SUMO activating enzyme activity)
GO:0043008 (ATP-dependent protein binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016567 (protein ubiquitination)
GO:0016925 (protein sumoylation)
GO:0043085 (positive regulation of catalytic activity)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
Wikipedia SAE1

Target Cross References - Protein

Human Protein Atlas ENSG00000142230
IntAct Q9UBE0
Open Targets ENSG00000142230
PharmGKB PA162402387
Reactome R-HSA-3065676 (SUMO is conjugated to E1 (UBA2:SAE1).)
R-HSA-3065678 (SUMO is transferred from E1 to E2 (UBE2I, UBC9).)
UniProt B2RDP5 B3KMQ2 F5GXX7 G3XAK6 O95717 Q9P020 Q9UBE0

Target Cross References - Domain

InterPro IPR000011 (UBQ/SUMO-activ_enz_E1-like.)
IPR000594 (ThiF_NAD_FAD-bd.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00899 (ThiF)

Target Cross References - Structure

PDBe 1Y8Q 1Y8R 3KYC 3KYD
CREDO 1Y8Q 1Y8R 3KYC 3KYD
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