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Target Report Card

Target Name and Classification

Target ID CHEMBL1615387
Preferred Name Nuclear receptor coactivator 1
Synonyms BHLHE74 | Class E basic helix-loop-helix protein 74 | NCOA1 | NCoA-1 | Nuclear receptor coactivator 1 | Protein Hin-2 | RIP160 | Renal carcinoma antigen NY-REN-52 | SRC-1 | SRC1 | Steroid receptor coactivator 1 | bHLHe74
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > src family

Target Components

Component Description Relationship Accession
Nuclear receptor coactivator 1 SINGLE PROTEIN Q15788

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095162 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 1 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084676
Ensembl ENSG00000084676
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0043005 (neuron projection)
GO Molecular Function GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0001105 (RNA polymerase II transcription coactivator activity)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0016922 (ligand-dependent nuclear receptor binding)
GO:0019899 (enzyme binding)
GO:0030331 (estrogen receptor binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0032403 (protein complex binding)
GO:0033142 (progesterone receptor binding)
GO:0035257 (nuclear hormone receptor binding)
GO:0042974 (retinoic acid receptor binding)
GO:0046965 (retinoid X receptor binding)
GO:0046983 (protein dimerization activity)
GO:0047485 (protein N-terminus binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0000435 (positive regulation of transcription from RNA polymerase II promoter by galactose)
GO:0002155 (regulation of thyroid hormone mediated signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007595 (lactation)
GO:0008584 (male gonad development)
GO:0009725 (response to hormone)
GO:0015721 (bile acid and bile salt transport)
GO:0021549 (cerebellum development)
GO:0021766 (hippocampus development)
GO:0021854 (hypothalamus development)
GO:0021987 (cerebral cortex development)
GO:0030521 (androgen receptor signaling pathway)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032570 (response to progesterone)
GO:0032870 (cellular response to hormone stimulus)
GO:0043065 (positive regulation of apoptotic process)
GO:0043967 (histone H4 acetylation)
GO:0044255 (cellular lipid metabolic process)
GO:0044849 (estrous cycle)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045925 (positive regulation of female receptivity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0060179 (male mating behavior)
GO:0060713 (labyrinthine layer morphogenesis)
GO:1904017 (cellular response to Thyroglobulin triiodothyronine)
GO:2001038 (regulation of cellular response to drug)
GO:2001141 (regulation of RNA biosynthetic process)
Wikipedia Nuclear_receptor_coactivator_1

Target Cross References - Protein

canSAR Q15788
Human Protein Atlas ENSG00000084676
IntAct Q15788
Guide to Pharmacology 2693
Open Targets ENSG00000084676
PharmGKB PA31470
Reactome R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-192105 (Synthesis of bile acids and bile salts.)
R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
R-HSA-400253 (Circadian Clock.)
UniProt O00150 O43792 O43793 Q13071 Q13420 Q15788 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR009110 (Nuc_rcpt_coact.)
IPR010011 (DUF1518.)
IPR011598 (bHLH_dom.)
IPR013767 (PAS_fold.)
IPR014920 (Nuc_rcpt_coact_Ncoa-typ.)
IPR014935 (SRC/p160_LXXLL.)
IPR017426 (Nuclear_rcpt_coactivator.)
IPR028819 (NCOA1.)
Pfam PF00010 (HLH)
PF00989 (PAS)
PF07469 (DUF1518)
PF08815 (Nuc_rec_co-act)
PF08832 (SRC-1)

Target Cross References - Structure

PDBe 1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE More...
CREDO 1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE More...