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Target Report Card

Target Name and Classification

Target ID CHEMBL1615384
Preferred Name Solute carrier family 12 member 5
Synonyms Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | SLC12A5 | Solute carrier family 12 member 5 | hKCC2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc12 family of cation-coupled chloride transporters

Target Components

Component Description Relationship Accession
Solute carrier family 12 member 5 SINGLE PROTEIN Q9H2X9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124140
Ensembl ENSG00000124140
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043025 (neuronal cell body)
GO:0043198 (dendritic shaft)
GO Molecular Function GO:0005215 (transporter activity)
GO:0015108 (chloride transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0015377 (cation:chloride symporter activity)
GO:0015379 (potassium:chloride symporter activity)
GO:0019901 (protein kinase binding)
GO:0022820 (potassium ion symporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006821 (chloride transport)
GO:0006873 (cellular ion homeostasis)
GO:0007268 (chemical synaptic transmission)
GO:0007612 (learning)
GO:0030644 (cellular chloride ion homeostasis)
GO:0035264 (multicellular organism growth)
GO:0040040 (thermosensory behavior)
GO:0042493 (response to drug)
GO:0055085 (transmembrane transport)
GO:0060996 (dendritic spine development)
GO:0071805 (potassium ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia Chloride_potassium_symporter_5

Target Cross References - Protein

Human Protein Atlas ENSG00000124140
Guide to Pharmacology 972
Open Targets ENSG00000124140
PharmGKB PA37814
Reactome R-HSA-426117 (Cation-coupled Chloride cotransporters.)
UniProt A2RTX2 Q5VZ41 Q9H2X9 Q9H4Z0 Q9ULP4

Target Cross References - Domain

InterPro IPR000076 (KCL_cotranspt.)
IPR004841 (AA-permease/SLC12A_dom.)
IPR004842 (SLC12A_fam.)
IPR018491 (SLC12_C.)
IPR030358 (KCC2.)
Pfam PF00324 (AA_permease)
PF03522 (SLC12)