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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1615382
Preferred Name Nuclear receptor coactivator 3
Synonyms ACTR | AIB-1 | AIB1 | Amplified in breast cancer 1 protein | BHLHE42 | CBP-interacting protein | Class E basic helix-loop-helix protein 42 | NCOA3 | NCoA-3 | Nuclear receptor coactivator 3 | RAC-3 | RAC3 | Receptor-associated coactivator 3 | SRC-3 | Steroid receptor coactivator protein 3 | TRAM-1 | TRAM1 | Thyroid hormone receptor activator molecule 1 | bHLHe42 | pCIP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > src family

Target Components

Component Description Relationship Accession
Nuclear receptor coactivator 3 SINGLE PROTEIN Q9Y6Q9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095161 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 3 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124151
Ensembl ENSG00000124151
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0016922 (ligand-dependent nuclear receptor binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0035257 (nuclear hormone receptor binding)
GO:0046966 (thyroid hormone receptor binding)
GO:0046983 (protein dimerization activity)
GO:0047485 (protein N-terminus binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0010628 (positive regulation of gene expression)
GO:0016573 (histone acetylation)
GO:0030521 (androgen receptor signaling pathway)
GO:0030522 (intracellular receptor signaling pathway)
GO:0035624 (receptor transactivation)
GO:0045618 (positive regulation of keratinocyte differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0071392 (cellular response to estradiol stimulus)
GO:2001141 (regulation of RNA biosynthetic process)
Wikipedia Nuclear_receptor_coactivator_3

Target Cross References - Protein

Human Protein Atlas ENSG00000124151
IntAct Q9Y6Q9
Open Targets ENSG00000124151
PharmGKB PA31472
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt A4LAZ5 Q0VF45 Q5JYD9 Q5JYE0 Q9BR49 Q9UPC9 Q9UPG4 Q9UPG7 Q9Y6Q9

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR009110 (Nuc_rcpt_coact.)
IPR010011 (DUF1518.)
IPR011598 (bHLH_dom.)
IPR013767 (PAS_fold.)
IPR014920 (Nuc_rcpt_coact_Ncoa-typ.)
IPR014935 (SRC/p160_LXXLL.)
IPR017426 (Nuclear_rcpt_coactivator.)
IPR028818 (NCOA3.)
IPR032565 (DUF4927.)
Pfam PF00989 (PAS)
PF07469 (DUF1518)
PF08815 (Nuc_rec_co-act)
PF08832 (SRC-1)
PF16279 (DUF4927)

Target Cross References - Structure

PDBe 3L3X 3L3Z