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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1615341
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor coactivator 2
Synonyms BHLHE75 | Class E basic helix-loop-helix protein 75 | NCOA2 | NCoA-2 | Nuclear receptor coactivator 2 | TIF2 | Transcriptional intermediary factor 2 | bHLHe75 | hTIF2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Nuclear receptor coactivator 2 SINGLE PROTEIN Q15596

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095163 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 2 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140396
Ensembl ENSG00000140396
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0004402 (histone acetyltransferase activity)
GO:0004871 (signal transducer activity)
GO:0016922 (ligand-dependent nuclear receptor binding)
GO:0035257 (nuclear hormone receptor binding)
GO Biological Process GO:0006351 (transcription, DNA-dependent)
GO:0044255 (cellular lipid metabolic process)
Wikipedia Nuclear_receptor_coactivator_2

Target Cross References - Protein

canSAR Q15596
Human Protein Atlas ENSG00000140396
IntAct Q15596
PharmGKB PA31471
Reactome REACT_15380 (Diabetes pathways.)
REACT_22258 (Metabolism of lipids and lipoproteins.)
TIMBAL PPAR-gamma
UniProt Q14CD2 Q15596

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001092 (HLH_DNA-bd_dom.)
IPR001610 (PAC.)
IPR008955 (Src1_rcpt_coact.)
IPR009110 (Nuc_rcpt_coact.)
IPR010011 (DUF1518.)
IPR011598 (HLH_DNA-bd.)
IPR013767 (PAS_fold.)
IPR014920 (Nuc_rcpt_coact_Ncoa-typ.)
IPR014935 (SRC-1.)
IPR017426 (Nuclear_rcpt_coactivator.)
Pfam PF00989 (PAS)
PF07469 (DUF1518)
PF08815 (Nuc_rec_co-act)
PF08832 (SRC-1)

Target Cross References - Structure

PDBe 1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U More...
CREDO 1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U More...
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