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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293316
Preferred Name Relaxin receptor 1
Synonyms LGR7 | Leucine-rich repeat-containing G-protein coupled receptor 7 | RXFP1 | Relaxin family peptide receptor 1 | Relaxin receptor 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > relaxin-like peptide receptor (family a gpcr) > relaxin receptor

Target Components

Component Description Relationship Accession
Relaxin receptor 1 SINGLE PROTEIN Q9HBX9

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108358 SERELAXIN Relaxin receptor 1 activator 3 Other Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171509
Ensembl ENSG00000171509
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
Wikipedia Relaxin/insulin-like_family_peptide_receptor_1

Target Cross References - Protein

Human Protein Atlas ENSG00000171509
IntAct Q9HBX9
Guide to Pharmacology 351
Open Targets ENSG00000171509
PharmGKB PA134868312
Pharos Q9HBX9 (Tbio)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-444821 (Relaxin receptors.)
UniProt B4DHD1 B4DTV2 Q2M215 Q3KU24 Q3KU25 Q3KU26 Q9HBX9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001611 (Leu-rich_rpt.)
IPR002172 (LDrepeatLR_classA_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR008112 (Relaxin_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR023415 (LDLR_class-A_CS.)
IPR032675 (L_dom-like.)
Pfam PF00001 (7tm_1)
PF00057 (Ldl_recept_a)
PF13855 (LRR_8)