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Target Report Card

Target Name and Classification

Target ID CHEMBL1293298
Preferred Name Peripheral myelin protein 22
Synonyms GAS-3 | GAS3 | Growth arrest-specific protein 3 | PMP-22 | PMP22 | Peripheral myelin protein 22
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Peripheral myelin protein 22 SINGLE PROTEIN Q01453

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109099
Ensembl ENSG00000109099
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005923 (bicellular tight junction)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043218 (compact myelin)
GO Molecular Function GO:0005515 (protein binding)
GO Biological Process GO:0007268 (chemical synaptic transmission)
GO:0007422 (peripheral nervous system development)
GO:0008219 (cell death)
GO:0008285 (negative regulation of cell proliferation)
GO:0010977 (negative regulation of neuron projection development)
GO:0030154 (cell differentiation)
GO:0032060 (bleb assembly)
GO:0042552 (myelination)
Wikipedia Peripheral_myelin_protein_22

Target Cross References - Protein

CGD Roussy-Levy syndrome; Charcot-Marie-Tooth syndrome, type 1A; Charcot-Marie-Tooth syndrome with deafness (type 1E); Neuropathy, hereditary, with liability to pressurve palsies; Dejerine-Sottas disease; Neuropathy, inflammatory demyelinating
Human Protein Atlas ENSG00000109099
IntAct Q01453
Open Targets ENSG00000109099
PharmGKB PA33444
UniProt Q01453 Q8WV01

Target Cross References - Domain

InterPro IPR003936 (PMP22.)
IPR004031 (PMP22/EMP/MP20/Claudin.)
IPR004032 (PMP22_EMP_MP20.)
Pfam PF00822 (PMP22_Claudin)