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Target Report Card

Target Name and Classification

Target ID CHEMBL1293287
Preferred Name Insulin-degrading enzyme
Synonyms Abeta-degrading protease | IDE | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Insulin-degrading enzyme SINGLE PROTEIN P14735

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119912
Ensembl ENSG00000119912
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005777 (peroxisome)
GO:0005782 (peroxisomal matrix)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0031597 (cytosolic proteasome complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001540 (beta-amyloid binding)
GO:0001618 (virus receptor activity)
GO:0001948 (glycoprotein binding)
GO:0003824 (catalytic activity)
GO:0004222 (metalloendopeptidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0017046 (peptide hormone binding)
GO:0031626 (beta-endorphin binding)
GO:0042277 (peptide binding)
GO:0042803 (protein homodimerization activity)
GO:0043130 (ubiquitin binding)
GO:0043559 (insulin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0008152 (metabolic process)
GO:0008286 (insulin receptor signaling pathway)
GO:0008340 (determination of adult lifespan)
GO:0010815 (bradykinin catabolic process)
GO:0010992 (ubiquitin homeostasis)
GO:0016032 (viral process)
GO:0016485 (protein processing)
GO:0032461 (positive regulation of protein oligomerization)
GO:0042447 (hormone catabolic process)
GO:0044257 (cellular protein catabolic process)
GO:0045861 (negative regulation of proteolysis)
GO:0046718 (viral entry into host cell)
GO:0050435 (beta-amyloid metabolic process)
GO:0051260 (protein homooligomerization)
GO:0051289 (protein homotetramerization)
GO:0051291 (protein heterooligomerization)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:1901142 (insulin metabolic process)
GO:1901143 (insulin catabolic process)
Wikipedia Insulin-degrading_enzyme

Target Cross References - Protein

Human Protein Atlas ENSG00000119912
IntAct P14735
Guide to Pharmacology 2371
Open Targets ENSG00000119912
PharmGKB PA29629
Reactome R-HSA-5689880 (Ub-specific processing proteases.)
UniProt B2R721 B7ZAU2 D3DR35 P14735 Q5T5N2

Target Cross References - Domain

InterPro IPR001431 (Pept_M16_Zn_BS.)
IPR007863 (Peptidase_M16_C.)
IPR011237 (Pept_M16_dom.)
IPR011249 (Metalloenz_LuxS/M16.)
IPR011765 (Pept_M16_N.)
IPR032632 (Peptidase_M16_M.)
Pfam PF00675 (Peptidase_M16)
PF05193 (Peptidase_M16_C)
PF16187 (Peptidase_M16_M)

Target Cross References - Structure

PDBe 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 More...
CREDO 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 More...