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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293287
Target Type SINGLE PROTEIN
Preferred Name Insulin-degrading enzyme
Synonyms Abeta-degrading protease | IDE | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Insulin-degrading enzyme SINGLE PROTEIN P14735

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119912
Ensembl ENSG00000119912
GO Cellular Component GO:0005615 (extracellular space)
GO:0005625 (soluble fraction)
GO:0009986 (cell surface)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004871 (signal transducer activity)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0007548 (sex differentiation)
GO:0010815 (bradykinin catabolic process)
GO:0044419 (interspecies interaction between organisms)
GO:0050435 (beta-amyloid metabolic process)
Wikipedia Insulin-degrading_enzyme

Target Cross References - Protein

Human Protein Atlas ENSG00000119912
Guide to Pharmacology 2371 (insulin-degrading enzyme)
PharmGKB PA29629
UniProt D3DR35 P14735 Q5T5N2

Target Cross References - Domain

InterPro IPR001431 (Pept_M16_Zn_BS.)
IPR007863 (Peptidase_M16_C.)
IPR011237 (Pept_M16_core.)
IPR011249 (Metalloenz_metal-bd.)
IPR011765 (Pept_M16_N.)
Pfam PF00675 (Peptidase_M16)
PF05193 (Peptidase_M16_C)

Target Cross References - Structure

PDBe 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI
CREDO 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI
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